T-cell receptor Vβ gene segment expression in diisocyanate-induced occupational asthma☆☆☆★★★

Bernstein, Jonathan A.; Munson, Jennifer L.; Lummus, Zana L.; Balakrishnan, Kamala; Leikauf, George D.

doi:10.1016/s0091-6749(97)70104-0

Cited by 53 publications

(42 citation statements)

References 23 publications

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“…T-helper type 2 (TH2) cells, which are crucial to common environmental asthma and proliferate vigorously in response to causative allergens in vitro, exhibit comparatively minimal responses to isocyanate. [3][4][5][6] Allergen-specific IgE, atopy, and elevated total serum IgE, which are strongly associated with common environmental asthma, are not generally associated with isocyanate asthma. 7,8 Thus, in contrast to common allergens, the cell types and effector molecules stimulated by isocyanate exposure remain unclear, including those that promote the development of pathogenic hypersensitivity responses vs. apparent "tolerance".…”

Section: Introductionmentioning

confidence: 99%

“…9,13,14 However, as mentioned above, antigenic isocyanate-albumin conjugates do not stimulate vigorous in vitro TH2 cellular responses. 4,7 Instead, limited recent studies suggest that human monocyte responses may play an important role in clinical isocyanate exposure outcome. 15,16 Monocytes are crucial cells of the innate arm of the immune system that circulate in an immature form, and differentiate into "tissue macrophages", dendritic cells and alveolar macrophages.…”

Section: Introductionmentioning

confidence: 99%

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Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates

Wisnewski

Liu

et al. 2008

Clin Experimental Allergy

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates

Wisnewski

Liu

et al. 2008

Clin Experimental Allergy

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“…Albumin adducts have been linked to the mechanism of occupational asthma caused by isocyanates [9,10]. Isocyanate-protein adducts trigger both immune responses and are probably the antigenic basis for isocyanate asthma [9,11,12]. Most toxicological and exposure data concerning aromatic isocyanates has been collected for 4,4'-methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI).…”

Section: Materials and Methods Workersmentioning

confidence: 99%

Albumin adducts and urinary metabolites resulting from occupational exposure to 1,5-naphthalene diisocyanate

Sepai

Sabbioni

2017

Int J Occup Med Environ Health

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Objectives: 1,5-Naphthalene diisocyanate (NDI) is used in the plastic industry as a curing agent. 1,5-Naphthalene diisocyanate is classified as a sensitizing agent. The objective of this study has been to develop biomonitoring methods for the evaluation of exposure to NDI. Material and Methods: We obtained blood and urine samples from a group of 20 male workers exposed to NDI. The workers answered a questionnaire about their exposure history, job description, the number of years with the company and the time spent working with NDI over the 10 days of the study. Total plasma, albumin, and urine were analyzed for the presence of 1,5-naphthalenediamine (NDA) after acid hydrolysis using gas chromatography-mass spectrometry (GC-MS). Results: 1,5-Naphthalenediamine was found in about 60% of the samples obtained from the workers. 1,5-Naphthalenediamine was obtained after acid hydrolysis of plasma, albumin, and urine at levels up to 1.5 pmol NDA/mg of plasma proteins, 1.15 pmol NDA/mg of albumin, and 55.3 pmol NDA/ml of urine, respectively. Conclusions: 1,5-Naphthalenediamine found in urine correlates best with the plasma levels (r = 0.91, p < 0.01). The albumin-adduct levels did not correlate with the NDI-specific immunoglobulin E (IgE) or total IgE present in the workers. The adduct and metabolite levels correlate with the air levels of NDI. Int J Occup Med Environ Health 2017;30(4):579-591

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“…Determination of the T cell receptor repertoire and HLA association may be useful for the evaluation of disease susceptibility by these two parameters 48,49) . Bernstein et al 50) reported evidence that the involvement of the TCR Vβ repertoire expression increased the expression Vβ1 and Vβ5 after in vitro stimulation in patients who were exposed to diisocyanate. Bignon et al 51) , Balboni et al 52) and Mapp et al 53) studied the HLA class II alleles' contribution to susceptibility or resistance to isocyanate-induced asthma in exposed workers.…”

Section: Immunological Mechanisms and Clinical Responsesmentioning

confidence: 99%

Review of the occupational exposure to isocyanates: Mechanisms of action

Nakashima

Takeshita

Morimoto

2002

Environ Health Prev Med

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Polyurethanes are useful polymers in a large variety of technical and consumer products that are generally made from diisocyanates and polyols or similar compounds. Toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are useful for polyurethane products. Isocyanates are reactive chemicals that can be handled without problems in manufacturing or technical environments. In general, consumers may only have contact with these chemicals on rare occasions. The objective of this study was to review the mechanisms of action of inhalation of isocyanates. This paper describes, in summary, the potential occupational exposure to isocyanates, the chemistry and reactivity of isocyanates, the results from genotoxicity studies, investigative toxicity studies, metabolism and results from epidemiology studies on isocyanate-exposed workers. The overall conclusion is that because humans are not exposed to high levels of respiratory isocyanate particles, concerns over the possible development of lung tumors should not be relevant. There are many mechanisms of action induced by isocyanates, but those entities are unclear. This is because these mechanisms act simultaneously and are complex.

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T-cell receptor Vβ gene segment expression in diisocyanate-induced occupational asthma☆☆☆★★★

Cited by 53 publications

References 23 publications

Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates

Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI–albumin conjugates

Albumin adducts and urinary metabolites resulting from occupational exposure to 1,5-naphthalene diisocyanate

Review of the occupational exposure to isocyanates: Mechanisms of action

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