T cell-mediated paraneoplastic ganglionitis - An autopsy case

Abstract

A 57-year-old woman presented with subacute sensory, ataxic neuronopathy. Clinical investigation revealed a right-sided non-small-cell lung cancer. Serum investigation for specific antineuronal antibodies was negative. Histology showed T lymphocytic infiltrates in dorsal root ganglia. The observed histological pattern is similar to that described in antibody-positive cases. Thus, these findings suggest similar pathways in specific antineuronal antibody-negative and -positive cases of paraneoplastic subacute sensory neuronopathy.

Differential, size-dependent sensory neuron involvement in the painful and ataxic forms of primary Sjögren's syndrome-associated neuropathy

“…Similar pathological findings are observed in paraneoplastic sensory neuropathy [42][43][44]. In paraneoplastic sensory neuropathy, CD8+ cytotoxic T cells are situated around the DRG and often indent the capsule of satellite cells to come in close attachment with DRG [42,43].…”

“…Similar pathological findings are observed in paraneoplastic sensory neuropathy [42][43][44]. In paraneoplastic sensory neuropathy, CD8+ cytotoxic T cells are situated around the DRG and often indent the capsule of satellite cells to come in close attachment with DRG [42,43]. Therefore, CD8+ T cellmediated cytotoxicity plays an important role in the pathogenesis of paraneoplastic sensory neuropathy, although onconeural antibodies, especially anti-Hu antibodies, are frequently found in this form of neuropathy [45].…”

Paraneoplastic necrotizing myelopathy with hypertrophy of the cauda equina

“…Therefore, the occurrence of paraneoplastic myelopathy suggests that the hypertrophy of the cauda equina represents an additional paraneoplastic feature. In contrast to paraneoplastic ganglionitis [2], we observed no inflammatory infiltrates and no neuronal degeneration in the dorsal root ganglia. Thus both the hypertrophic cauda and the necrotic spinal cord lacked relevant inflammation and specific changes in the blood vessels.…”

A predominantly left upper limb sensory neuronopathy as a manifestation of a metastatic neuroendocrine malignancy

“…12,13 Paraneoplastic subacute sensory neuronopathies can occur without the presence of anti-neuronal (in particular, anti-Hu) antibodies. 1,2,14 After the tissue diagnosis was made, treatment options were discussed with the patient and her family. Further therapy was declined and palliative therapy was given.…”