T-Cell Lymphoblastic Lymphoma with Cutaneous Involvement in a Child: A Rare Case Report

Chen, Jiaoquan; Tian, Xin; Yu, Nanji; Peng, Liqian; Zhu, Huilan

doi:10.2147/ccid.s376523

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Furthermore, by coincidence, PTCL cells may be the TCR gamma/delta type and involve the skin, which is uncommon for T-ALL/T-LBL. 4 , 6 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, by coincidence, PTCL cells may be the TCR gamma/delta type and involve the skin, which is uncommon for T-ALL/T-LBL. 4,6 Two cases of their metachronous occurrence have previously been reported, in which transformation from T-ALL (T-ALL/LBL, NOS) to PTCL was suggested. 2 These cases shared the following common features: PTCL occurred after primary therapy for T-ALL with approximately four-month and four-year intervals, was the γδ type, and involved the skin.…”

Section: Discussionmentioning

confidence: 99%

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Coincidence of <i>de novo</i> T-lymphoblastic lymphoma and cutaneous gamma/delta peripheral T-cell lymphoma

Satoh,

Kayano,

Kohri

et al. 2023

J Clin Exp Hematopathol

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The coincidence of acute T-lymphoblastic leukemia/lymphoma, NOS (T-ALL/LBL), and peripheral T-cell lymphoma (PTCL) is unusual, and there have only been a few cases of their metachronous occurrence. In these cases, PTCLs emerged as recurrence after primary therapy for primary T-ALL, were the rare gamma/delta type, and uncommonly involved skin for T-ALL/LBL. We herein report the first case of de novo T-LBL that coincided with cutaneous gamma/delta PTCL before primary therapy. A 70-year-old man presented with systemic lymphadenopathy. Lymph node biopsy revealed a massive proliferation of lymphoblastoid cells; immunohistochemically, they were positive for TdT/CD1a/CD99, and cytoplasmic CD3ε, CD4, and CD8 and were negative for T-cell receptor (TCR) βf-1. A few TCRδ-positive cells were intermingled. Atypically, TIA was focally positive, whereas granzyme/perforin was negative. Multiple papules and plaques emerged on the trunk before the initiation of treatment for T-LBL. Skin biopsy revealed a massive proliferation of medium-to-large atypical lymphoid cells that were TdT/CD1a-negative mature T-cells; they were negative for TCRβf1 and CD4, and positive for TCRδ, CD5, CD8, CD56, TIA, granzyme B, and perforin. A conventional PCR analysis of TCRG showed no identical clonal band between the two tumors. The skin lesion was diagnosed as cutaneous gamma/delta T-cell lymphoma. Whether the lesion was primary or a transformation of T-LBL was unclear. After treating with reduced hyper-CVAD/MA targeting T-LBL, molecular complete remission was achieved. When an uncommon cutaneous lesion emerges in the course of T-ALL/LBL, both need to be evaluated pathologically and genetically, whether de novo or recurrent, assuming the possibility of coincident gamma/delta PTCL.

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“…Furthermore, by coincidence, PTCL cells may be the TCR gamma/delta type and involve the skin, which is uncommon for T-ALL/T-LBL. 4 , 6 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Coincidence of <i>de novo</i> T-lymphoblastic lymphoma and cutaneous gamma/delta peripheral T-cell lymphoma

Satoh,

Kayano,

Kohri

et al. 2023

J Clin Exp Hematopathol

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Lymphoblastic lymphoma presenting as soft-tissue swelling – A single-center experience

Nair,

Thambi,

Narayanan

et al. 2024

Iraqi Journal of Hematology

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BACKGROUND: Lymphoblastic lymphomas (LBL) are a rare, aggressive type of non-Hodgkin lymphomas and constitute 2% of all lymphomas. It is classified as T-lymphoblastic lymphoma (T-LBL) and B lymphoblastic lymphoma (B-LBL) and resembles acute lymphoblastic leukemia (ALL), with no or limited bone-marrow involvement. LBL rarely present as soft-tissue swellings. Soft-tissue involvement is more common in B-LBL than in T-LBL. They occur predominantly in adolescents and young adults and have a prognosis similar to ALL. OBJECTIVE: p>The aim was to study the clinical characteristics, treatment response, and survival of patients with lymphoblastic lymphoma presenting with soft-tissue swelling. SETTINGS AND DESIGN: This was a retrospective study of eight adolescent and adult patients with lymphoblastic lymphoma presenting with soft-tissue swelling conducted in the Department of Medical Oncology at a tertiary cancer center in India. STATISTICAL ANALYSIS: The baseline patient characteristics, treatment details, and response assessment were analyzed using descriptive statistics. Overall survival (OS) and progression-free survival were obtained by the Kaplan–Meier method, using the SPSS version. 11. MATERIALS AND METHODS: We present the clinical features, imaging, diagnosis, treatment, and outcome of eight cases of lymphoblastic lymphoma presenting with soft-tissue swellings. Patients above 14 years of age treated over 12 years were included in the study. RESULTS: There were five males and three females. The median age at diagnosis was 24 years. Common presenting complaints were swelling, pain, and paraparesis. The sites of involvement were the epidural mass, thigh, calf, breast, and anterior chest wall. The diagnosis was confirmed by immunohistochemistry. Seven patients were diagnosed with B-LBL and one with T-LBL. They were treated with intensive chemotherapy (six patients with Berlin–Frankfurt–Munster protocol and two with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone). Three patients received consolidation radiotherapy and one received palliative radiotherapy. Seven patients attained remission after induction chemotherapy and four of them are currently alive at a median follow-up of 48 months. The 2-year OS was 71.4%. CONCLUSION: Even though rare, lymphoblastic lymphoma should be considered a differential diagnosis in patients presenting with soft-tissue swelling and should be managed with systemic chemotherapy similar to ALL.

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T-Cell Lymphoblastic Lymphoma with Cutaneous Involvement in a Child: A Rare Case Report

Cited by 2 publications

References 22 publications

Coincidence of <i>de novo</i> T-lymphoblastic lymphoma and cutaneous gamma/delta peripheral T-cell lymphoma

Coincidence of <i>de novo</i> T-lymphoblastic lymphoma and cutaneous gamma/delta peripheral T-cell lymphoma

Lymphoblastic lymphoma presenting as soft-tissue swelling – A single-center experience

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