2024
DOI: 10.1126/sciimmunol.adj7124
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T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection

Sharon Kagan Ben Tikva,
Neta Gurwitz,
Ehud Sivan
et al.

Abstract: Antibody affinity maturation occurs in secondary lymphoid organs within germinal centers (GCs). At these sites, B cells mutate their antibody-encoding genes in the dark zone, followed by preferential selection of the high-affinity variants in the light zone by T cells. The strength of the T cell–derived selection signals is proportional to the B cell receptor affinity and to the magnitude of subsequent Myc expression. However, because the lifetime of Myc mRNA and… Show more

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