T cell epitopes of Per a 10 modulate local-systemic immune responses and airway inflammation by augmenting Th1 and T regulatory cell functions in murine model

Govindaraj, Dhanapal; Sharma, Swati; Singh, Naresh; Arora, Naveen

doi:10.1016/j.imbio.2019.01.003

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…A model of airway allergic disease was generated by sensitization of mice with cockroach extract and challenge with purified Per a 10. 141 Within this model, an immunotherapy protocol was developed wherein mice were treated with Per a 10-derived T cell peptide. Treatment with peptides T-P8 and T-P10 reduced recruitment of inflammatory cells to airways, lowered specific IgE, caused induction of IgG2a antibodies, immune deviation towards a Th1 cytokine milieu, suppression of Th2 cytokines in BALF, resolution of lung inflammation and induction of T regulatory cell mediated peripheral tolerance.…”

Section: Cockroach Allergensmentioning

confidence: 99%

“…Treatment with peptides T-P8 and T-P10 reduced recruitment of inflammatory cells to airways, lowered specific IgE, caused induction of IgG2a antibodies, immune deviation towards a Th1 cytokine milieu, suppression of Th2 cytokines in BALF, resolution of lung inflammation and induction of T regulatory cell mediated peripheral tolerance. 141 Another study in mice investigated the therapeutic effects of an intranasal cockroach allergy vaccine made of purified natural Per a 9 (arginine kinase, AK), entrapped in liposome. 142 After provocation with cockroach extract, mice treated with liposome-entrapped purified natural Per a 7 showed attenuated airway inflammation and a shift of allergic Th2 to Th1 and Treg responses.…”

Section: Cockroach Allergensmentioning

confidence: 99%

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The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources

Caraballo

Valenta

Puerta

et al. 2020

World Allergy Organization Journal

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A large number of allergens have been discovered but we know little about their potential to induce inflammation (allergenic activity) and symptoms. Nowadays, the clinical importance of allergens is determined by the frequency and intensity of their IgE antibody binding (allergenicity). This is a rather limited parameter considering the development of experimental allergology in the last 20 years and the criteria that support personalized medicine. Now it is known that some allergens, in addition to their IgE antibody binding properties, can induce inflammation through non IgE mediated pathways, which can increase their allergenic activity. There are several ways to evaluate the allergenic activity, among them the provocation tests, the demonstration of non-IgE mediated pathways of inflammation, case control studies of IgE-binding frequencies, and animal models of respiratory allergy. In this review we have explored the current status of basic and clinical research on allergenic activity of indoor allergens and confirm that, for most of them, this important property has not been investigated. However, during recent years important advances have been made in the field, and we conclude that for at least the following, allergenic activity has been demonstrated:

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Section: Cockroach Allergensmentioning

confidence: 99%

Section: Cockroach Allergensmentioning

confidence: 99%

The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources

Caraballo

Valenta

Puerta

et al. 2020

World Allergy Organization Journal

View full text Add to dashboard Cite

show abstract

“…Studies have indicated that increased secretion of Th1-related cytokines and decreased Th2-related cytokine levels may prevent excessive IgE production [35]. Reportedly, the IgG1 immune complex is responsible for class-switching to Th2 cytokines, and IgG2a is oriented toward Th1 cytokine immune deviation [36]. In addition, adjusting the balance of Th1/Th2 cytokines to inhibit mast cell activation, then decreasing the levels of IgG1 and increasing IgG2a has a significant anti-allergic inflammatory effect [37].…”

Section: Discussionmentioning

confidence: 99%

Topical Spilanthol Inhibits MAPK Signaling and Ameliorates Allergic Inflammation in DNCB-Induced Atopic Dermatitis in Mice

Huang

et al. 2019

IJMS

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Atopic dermatitis (AD) is a recurrent allergic skin disease caused by genetic and environmental factors. Patients with AD may experience immune imbalance, increased levels of mast cells, immunoglobulin (Ig) E and pro-inflammatory factors (Cyclooxygenase, COX-2 and inducible NO synthase, iNOS). While spilanthol (SP) has anti-inflammatory and analgesic activities, its effect on AD remains to be explored. To develop a new means of SP, inflammation-related symptoms of AD were alleviated, and 2,4-dinitrochlorobenzene (DNCB) was used to induce AD-like skin lesions in BALB/c mice. Histopathological analysis was used to examine mast cells and eosinophils infiltration in AD-like skin lesions. The levels of IgE, IgG1 and IgG2a were measured by enzyme-linked immunosorbent assay (ELISA) kits. Western blot was used for analysis of the mitogen-activated protein kinase (MAPK) pathways and COX-2 and iNOS protein expression. Topical SP treatment reduced serum IgE and IgG2a levels and suppressed COX-2 and iNOS expression via blocked mitogen-activated protein kinase (MAPK) pathways in DNCB-induced AD-like lesions. Histopathological examination revealed that SP reduced epidermal thickness and collagen accumulation and inhibited mast cells and eosinophils infiltration into the AD-like lesions skin. These results indicate that SP may protect against AD skin lesions through inhibited MAPK signaling pathways and may diminish the infiltration of inflammatory cells to block allergic inflammation.

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NLRP3/GSDMD mediated pyroptosis induces lung inflammation susceptibility in diesel exhaust exposed mouse strains

Singh,

Nagar,

Roy

et al. 2024

Gene

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T cell epitopes of Per a 10 modulate local-systemic immune responses and airway inflammation by augmenting Th1 and T regulatory cell functions in murine model

Cited by 7 publications

References 36 publications

The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources

The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources

Topical Spilanthol Inhibits MAPK Signaling and Ameliorates Allergic Inflammation in DNCB-Induced Atopic Dermatitis in Mice

NLRP3/GSDMD mediated pyroptosis induces lung inflammation susceptibility in diesel exhaust exposed mouse strains

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