T-Cell Depletion with Campath 1 to Prevent GVHD

Minor histocompatibility antigen H-Y is expressed on human hematopoietic progenitor cells.

“…Recently, T lymphocyte depletion ofthe marrow graft, as a method to prevent GVHD, has been found to be associated with an increase in the incidence of graft failures in HLA identical transplants (14)(15)(16)(17). Since the incidence can be reduced by a more intensive pretransplant immunosuppressive treatment of the recipient (18-20), it is likely that an immunemediated rejection is involved in these cases.…”