1999
DOI: 10.1097/00042737-199910000-00006
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T-cell co-stimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa

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Cited by 48 publications
(48 citation statements)
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“…In contrast to the abundant expression of B7-H1, B7-DC expression in the inflamed lung was limited, especially on lung macrophages. Consistent with previous reports (6,(41)(42)(43), we observed reduced expression of CD86 and B7-DC on lung macrophages compared with other peripheral tissues. Similar findings were reported in the CNS of mice with experimental autoimmune encephalomyelitis (44).…”
Section: Discussionsupporting
confidence: 93%
“…In contrast to the abundant expression of B7-H1, B7-DC expression in the inflamed lung was limited, especially on lung macrophages. Consistent with previous reports (6,(41)(42)(43), we observed reduced expression of CD86 and B7-DC on lung macrophages compared with other peripheral tissues. Similar findings were reported in the CNS of mice with experimental autoimmune encephalomyelitis (44).…”
Section: Discussionsupporting
confidence: 93%
“…In addition, Meijssen et al reported expression of CD14 mRNA in intestinal epithelial cells of IL-2 Ϫ/Ϫ mice, which develop inflammatory bowel disease resembling human ulcerative colitis (36). These data suggest that the healthy mucosal microenvironment down-regulates mCD14 expression but that inflammatory processes lead to its up-regulation (13,14,19,20,36,42,46).…”
Section: Discussionmentioning
confidence: 98%
“…Furthermore, the anti-inflammatory cytokines IL-4, a prevalent cytokine of the mucosal microenvironment, and IL-13 were reported to down-regulate CD14 expression on monocytes (6,30). Interestingly, human lamina propria macrophages almost do not express mCD14 (19,46) unless inflammation is present, such as in inflammatory bowel disease (20,42) or celiac disease (48). In mice, TNF-␣ and IL-1␤ were shown to induce CD14 mRNA in nonintestinal epithelial cells (13,14).…”
Section: Discussionmentioning
confidence: 99%
“…They represent one of the largest compartments of the mononuclear phagocyte system in the body (1) and constitute 10 -20% of the mononuclear cells in the lamina propria (2)(3)(4). Intestinal macrophages (IMAC) 4 from normal noninflamed mucosa show a specific nonreactive phenotype with down-regulated monocyte/macrophage surface receptors such as CD14, CD16, CD80, or CD86 (5)(6)(7)(8)(9)(10)(11). It is generally assumed that these nonreactive, anergic cells inhibit immunological responses to Ags present in the intestine under normal conditions.…”
mentioning
confidence: 99%