T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues

Coupland, Sarah E.; Foss, Hans‐Dieter; Assaf, Chalid; Auw-Haedrich, Claudia; Anastassiou, Gerassimos; Anagnostopoulos, Ioannis; Hummel, Michael; Karesh, James W.; Lee, William R.; Stein, Harald

doi:10.1016/s0161-6420(99)90492-x

Cited by 145 publications

(45 citation statements)

References 50 publications

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“…Non-B-cell lymphomas represent only 3% of the primary ocular, orbital and adnexal lymphoproliferative lesions; hence, NKTL is infrequent in the orbit [2,3]. Several studies have reported ophthalmic complications of nasal NKTL, which include uveitis, vitritis, orbital infiltration and even retinal complications speculated to result from severe vitreous inflammation such as macular hole and retinal detachment [1,2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported ophthalmic complications of nasal NKTL, which include uveitis, vitritis, orbital infiltration and even retinal complications speculated to result from severe vitreous inflammation such as macular hole and retinal detachment [1,2,3]. The intraocular fluid in these cases, however, may not reveal any tumor cells, unlike in high-grade cerebral or ocular B-cell lymphomas [1].…”

Section: Discussionmentioning

confidence: 99%

“…Natural killer T-cell lymphoma (NKTL) is extremely rare in the orbit [1,2]. It characteristically involves the nose and paranasal sinuses (PNS) with secondary extension into the orbit [1,2,3].…”

Section: Introductionmentioning

confidence: 99%

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Isolated Extranodal Natural Killer T-Cell Lymphoma of the Orbit in a Young Patient: Complete Regression with the SMILE Regimen

Meel¹,

Dhiman²,

Wadhwani³

et al. 2016

Ocul Oncol Pathol

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Purpose: Natural killer T-cell lymphoma (NKTL) is a highly malignant tumor that typically arises in the nose and/or paranasal sinuses. Isolated orbital involvement by NKTL is extremely rare, and only few case reports exist in the literature. Herein, we report a case of primary orbital NKTL in a young patient who showed very good response to chemotherapy with the SMILE regimen. Methods: A 28-year-old healthy female presented to us with epiphora and fullness of the lower eyelid. She had previously been diagnosed as orbital pseudotumor and was prescribed oral steroids. However, there was no response to the treatment. She also had a history of recurrent sinusitis. An incision biopsy revealed NKTL. A systemic workup did not reveal any other site of involvement. The patient received 6 cycles of chemotherapy (SMILE) and external beam radiotherapy. Results: The tumor showed complete regression after 2 cycles of chemotherapy. The patient is disease free at 24 months of follow-up. Conclusion: Reported median survival for primary orbital NKTL is extremely poor. This is perhaps the first report of a primary orbital NKTL demonstrating a remarkable treatment response to a newer chemotherapy regimen (SMILE) in combination with radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Isolated Extranodal Natural Killer T-Cell Lymphoma of the Orbit in a Young Patient: Complete Regression with the SMILE Regimen

Meel¹,

Dhiman²,

Wadhwani³

et al. 2016

Ocul Oncol Pathol

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“…In another series of 73 patients with ocular adnexal lymphoproliferative disease, 44 (63%) patients were diagnosed with extranodal marginal zone lymphoma, but only 1 (1.5%) with natural killer cell lymphoma (NKCL) [9]. In a series of 7 patients reported from Germany, only 1 was confirmed with NKTL [10]. The clinical manifestations of NKTL included a short clinical course with rapid deterioration.…”

Section: Discussionmentioning

confidence: 99%

Primary Ocular Natural Killer/T-Cell Lymphomas: Clinicopathologic Features and Diagnosis

Yang

Luo

et al. 2007

Ophthalmologica

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Purpose: Primary ocular natural killer/T-cell lymphoma (NKTL) is rare. This study aims to characterize the clinical manifestations, diagnosis and treatment methods of primary ocular NKTL. Methods: Clinical data of seven patients with ocular NKTL from 1982 to 2004 were collected. A morphologic, immunohistochemical and molecular analysis was undertaken. Results: Clinical manifestations and computed tomography of the patients were typical. LCA CD56 CD3Ε Ki-67 granzyme B (GrB) and T-cell intracellular antigen-1(TIA-1) were mostly positive. Clonal T-cell-receptor gene rearrangements of five patients showed negative findings, and the detection of Epstein-Barr virus showed positive. All patients died 5 months to 28 months after presentation. Conclusion: Ocular NKTL is a highly aggressive clinical course with poor prognosis. The diagnosis relies on clinicopathologic findings.

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“…The prognosis is poor for individuals with PCNSL, with a median survival ranging from 1 to 8 years depending on factors such as age and Karnofsky performance status [1,2]. While typically of B-cell origin (diffuse large B-cell lymphoma), rare cases of primary T-cell PVRL occur [3] but are usually secondary to human T-cell lymphotropic virus type 1 or metastatic T-cell lymphoma [1,4,5]. Among immunocompetent individuals, the peak incidence of PVRL is between the ages of 50 and 70 years.…”

Section: Introductionmentioning

confidence: 99%

Intraocular Lymphoma Models

Aronow¹,

Shen²,

Hochman³

et al. 2015

Ocul Oncol Pathol

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Primary vitreoretinal lymphoma (PVRL) is a subtype of primary central nervous system lymphoma (PCNSL), a high-grade, extranodal, non-Hodgkin's lymphoma, predominantly of B-cell origin. PVRL is an aggressive disease with a poor prognosis. Human studies are not ideally suited for the study of intraocular lymphoma pathogenesis or treatment strategies due to the rare nature of the disease, its variable presentation, limited volume of available ocular fluids, and fragility of sampled lymphoma cells. Animal models have been critical in making progress in understanding intraocular lymphoma pathogenesis and investigating potential therapeutic strategies. Early murine models for intraocular lymphoma used intraperitoneal injection of mouse T-cell lymphomas. This was followed by intravitreal T-cell murine models. More recent murine models have used B-cell lymphomas to more closely mimic human disease. The most current B-cell lymphoma models employ a combined approach of inoculating both the mouse vitreous cavity and brain. The challenge in murine models for intraocular lymphoma lies in recreating the clinical features, disease behavior, molecular profile, systemic immunity, and the microenvironment observed in human disease. In the future, animal models will continue to be central to furthering our understanding of the disease and in the investigation of potential treatment targets.

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T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues

Cited by 145 publications

References 50 publications

Isolated Extranodal Natural Killer T-Cell Lymphoma of the Orbit in a Young Patient: Complete Regression with the SMILE Regimen

Isolated Extranodal Natural Killer T-Cell Lymphoma of the Orbit in a Young Patient: Complete Regression with the SMILE Regimen

Primary Ocular Natural Killer/T-Cell Lymphomas: Clinicopathologic Features and Diagnosis

Intraocular Lymphoma Models

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