T cell abundance in blood predicts acute organ toxicity in chemoradiotherapy for head and neck cancer

Beschel, L. Milena; Leu, Martin; Reichardt, Sybille D.; Rave-Fränk, Margret; Schirmer, Markus; Stadelmann, Christine; Canis, Martin; Wolff, Hendrik A.; Reichardt, Holger M.

doi:10.18632/oncotarget.11677

Cited by 3 publications

(2 citation statements)

References 38 publications

(46 reference statements)

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“…In addition, postoperative radiotherapy was discussed on an individual basis if other risk factors were present (e.g., L1, V1 status, patients with single positive lymph nodes without extracapsular extension, patients with recurrent disease) [ 16 , 17 , 18 , 19 ]. Beschel et al previously described the radiotherapy procedures [ 20 ]. Before radiotherapy, patients received a comprehensive dental evaluation by the University Medical Center dentists.…”

Section: Methodsmentioning

confidence: 99%

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Postoperative Radiochemotherapy Using Modern Radiotherapy Techniques in Elderly Patients with Head and Neck Squamous Cell Carcinoma: The Challenge of Weighing Up Benefits and Harms of Treatment Modalities in Clinical Practice

Leu

Patzer

Guhlich

et al. 2021

Cancers

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Locally advanced head and neck squamous cell carcinomas (HNSCC) are often managed with surgery followed by postoperative radiochemotherapy (RCT). With the general increase in life expectancy, the proportion of elderly patients with HNSCC is expected to grow rapidly. Until now, a deeper understanding of specific management strategies for these patients in clinical routine was lacking. In the present study, we compared elderly patients (≥70 years, n = 52) and younger patients (n = 245) treated with postoperative RCT for HNSCC at our tertiary cancer center. All patients were irradiated with modern radiotherapy techniques (IMRT/VMAT). Patients ≥70 years of age had more comorbidities. Additionally, elderly patients less frequently received concomitant systemic treatment. The rates of mucositis and dermatitis were lower in patients ≥70 years. Elderly patients had significantly worse overall and progression-free survival. Locoregional and distant control were comparable in elderly and younger patients. In conclusion, postoperative RCT is a safe and effective treatment option in patients ≥70 years. In light of comorbidities and poor overall survival rates, benefits and harms of radiotherapy and concomitant systemic treatment should be weighed carefully. When exclusively applying up-to-date radiotherapy techniques with, at the same time, careful use of concomitant systemic therapy, favorable acute toxicity profiles are achieved.

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Section: Methodsmentioning

confidence: 99%

“…The procedures in systemic treatment were already described previously [ 20 , 27 , 28 ]. Concomitant systematic treatment was standardly applied in patients with extracapsular extension and R1 tumors.…”

Section: Methodsmentioning

confidence: 99%

Postoperative Radiochemotherapy Using Modern Radiotherapy Techniques in Elderly Patients with Head and Neck Squamous Cell Carcinoma: The Challenge of Weighing Up Benefits and Harms of Treatment Modalities in Clinical Practice

Leu

Patzer

Guhlich

et al. 2021

Cancers

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Emerging evidence for adapting radiotherapy to immunotherapy

et al. 2023

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Evaluation of the efficacy of chemoradiotherapy in cervical cancer using diffusion-weighted imaging and apparent diffusion coefficient

Ju¹

2016

OTT

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ObjectiveThis study aims to evaluate the efficacy of chemoradiotherapy (CRT) in cervical cancer using diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) values.MethodsA total of 71 patients with cervical cancer were enrolled in this study. All patients underwent conventional magnetic resonance imaging and DWI scanning before CRT and at 7, 14, 21 days, and 6 months after CRT. These patients were divided into the complete response (CR) and non-CR groups according to the response evaluation criteria in solid tumors criteria. Receiver operating characteristic (ROC) curve was used to evaluate the accuracy of ADC values in predicting the efficacy of CRT in cervical cancer.ResultsCompared with before-CRT treatment, tumor volumes were reduced and ADC values were elevated in both CR and non-CR groups after CRT treatment. At 21 days after CRT, tumor volumes in the CR group were smaller than those in the non-CR group. During the period of 21 days to 6 months after CRT, tumor regression rate and the increased rate of ADC values in the CR group were higher than those in the non-CR group. ROC curves revealed that the increased rate of ADC values at 21 days after CRT was the optimal time point for the prediction of CRT efficacy in cervical cancer, with the area under the curve, sensitivity, and specificity of 0.775, 92.7%, and 62.5%, respectively.ConclusionOur study provides evidence that the increased rate of ADC at 21 days after CRT might be a promising tool for predicting the efficacy of CRT in cervical cancer.

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T cell abundance in blood predicts acute organ toxicity in chemoradiotherapy for head and neck cancer

Cited by 3 publications

References 38 publications

Postoperative Radiochemotherapy Using Modern Radiotherapy Techniques in Elderly Patients with Head and Neck Squamous Cell Carcinoma: The Challenge of Weighing Up Benefits and Harms of Treatment Modalities in Clinical Practice

Postoperative Radiochemotherapy Using Modern Radiotherapy Techniques in Elderly Patients with Head and Neck Squamous Cell Carcinoma: The Challenge of Weighing Up Benefits and Harms of Treatment Modalities in Clinical Practice

Emerging evidence for adapting radiotherapy to immunotherapy

Evaluation of the efficacy of chemoradiotherapy in cervical cancer using diffusion-weighted imaging and apparent diffusion coefficient

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