T-Cadherin Stimulates Melanoma Cell Proliferation and Mesenchymal Stromal Cell Recruitment, but Inhibits Angiogenesis in a Mouse Melanoma Model

Рубина, К. А.; Yurlova, E. I.; Sysoeva, Veronika; Semina, Ekaterina V.; Калинина, Н.И.; Poliakov, Alexei; Mikhaylova, I. N.; Andronova, N. A.; Treshalina, H. M.

doi:10.5772/53350

Cited by 2 publications

(2 citation statements)

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“…Contradictory results have been demonstrated for a fully mouse model of melanoma, where up-regulated T-cadherin acted oppositely at the same time: as a positive and a negative regulator of mouse melanoma development [91]. Namely, it has been shown that the overexpression of T-cadherin in B16F10 mouse melanoma promotes primary tumour growth due to the recruitment of mesenchymal stromal cells, as well as enhances cell motility, invasiveness and metastasis formation in BDF1 mice in parallel with the inhibition of neovascularization of primary melanoma sites [91]. This apparent discrepancy has been explained by the recent study, which showed that in the species-specific environment T-cadherin-overexpressed melanoma cells up-regulated the level of pro-oncogenic integrins, chemokines, adhesion molecules and extracellular matrix components, which in turn increased the invasive potential of tumour cells [92].…”

Section: T-cadherinmentioning

confidence: 91%

“…Furthermore, ectopic up-regulated T-cadherin sensitizes the apoptosis induced by treatment with CD95/Fas antibody CH-11 [90]. Contradictory results have been demonstrated for a fully mouse model of melanoma, where up-regulated T-cadherin acted oppositely at the same time: as a positive and a negative regulator of mouse melanoma development [91]. Namely, it has been shown that the overexpression of T-cadherin in B16F10 mouse melanoma promotes primary tumour growth due to the recruitment of mesenchymal stromal cells, as well as enhances cell motility, invasiveness and metastasis formation in BDF1 mice in parallel with the inhibition of neovascularization of primary melanoma sites [91].…”

Section: T-cadherinmentioning

confidence: 92%

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Cadherins and their Role in Malignant Transformation: Implications for Skin Cancer Progression

Janik¹,

Hoja-Łukowicz²,

Przybyło³

2016

Human Skin Cancer, Potential Biomarkers and Therapeutic Targets

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Cadherins are a large family of Ca 2+ dependent adhesion proteins. They are transmembrane or closely related to membrane glycoproteins localized in specialized adhesive junction. The expression of various cadherins may be concomitant with cancer progression steps and the term 'cadherin switch' has been created due to the observation of down-regulation of E-cadherin (suppressor of metastatic potential) and up-regulation of N-cadherin (promoter of metastatic potential) expression during tumour progression. These changes are thought to be closely related to epithelial-to-mesenchymal transition of cells of many different types of cancer including skin cancers, and accompany the increase of their motility and invasion abilities resulting in the metastasis formation. The cadherin polypeptide is a potential substrate for post-translational modification, for example, N-glycosylation, and its important role in the regulation of cadherin function has been described. The changed glycosylation of cadherins has been described in various skin cancers including melanoma and was consistent with cadherins' role in epithelial-to-mesenchymal transition. The detailed analysis of cadherin expression and cadherin-related glycosylation changes taking place during malignant transformation could be a key for better understanding of the nature of this process and may open new opportunities for the creation of more effective anticancer therapeutics and diagnostic tools.

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Section: T-cadherinmentioning

confidence: 91%