volume 107, issue 7, P2797-2805 2006
DOI: 10.1182/blood-2005-08-3103
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Abstract: V␣14i natural killer T (NKT)-cell function has been implicated in a number of disease conditions. The molecular events that drive V␣14i NKT-cell development remain elusive. We recently showed that T-bet is required for the terminal maturation of these cells. Here we identify some of the genetic targets of T-bet during V␣14i NKT-cell lineage development. Microarray gene-expression analyses on developing V␣14i NKT cells were performed and provide a molecular framework to study these maturation events. In vitro …

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