T-B cell epitope peptides induce protective immunity against Mycoplasma pneumoniae respiratory tract infection in BALB/c mice

Comprehending B-Cell Epitope Prediction to Develop Vaccines and Immunodiagnostics

“…Nevertheless, BCEP can support the development of vaccines and immunodiagnostics provided that its limitations are adequately comprehended and addressed. be produced from peptides comprising disordered BCEs of selected target proteins (e.g., pathogen virulence factors), to elicit production of antipeptide antibodies (i.e., peptide antibodies (22)) that can neutralize the biological activity of the proteins (4,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). Such an approach is viable where the BCEs are disordered in both the peptides and the proteins; but if the BCEs are conformationally constrained (e.g., folded) in the proteins, their binding by the antipeptide antibodies may fail to occur, as is thought to be the case among unsuccessful attempts at peptide-based vaccine development (16).…”