T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update

Vliet, Chris Van; Spagnolo, Dominic V.

doi:10.1016/j.pathol.2019.10.001

Cited by 74 publications

(115 citation statements)

References 95 publications

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“…MEITL is an intestinal lymphoma with monomorphic small to medium-sized cells with minimal pleomorphism. Majority of lymphoma cells are CD2+, CD3+, CD7+, CD8+, CD56+, CD4-, CD5-and CD 30- [2]. This patient was positive for CD 3, CD 7, CD 8, CD 45 and negative for CD 5 and CD 30, making MEITL the most likely diagnosis.…”

Section: Discussionmentioning

confidence: 82%

“…This patient was positive for CD 3, CD 7, CD 8, CD 45 and negative for CD 5 and CD 30, making MEITL the most likely diagnosis. There are exceptions to this rule with cases of CD 8-and CD 56-MEITL lymphoma described [2]. Usually, patients present with intestinal perforation, obstruction or vague abdominal complaints.…”

Section: Discussionmentioning

confidence: 99%

“…Other less common presenting symptoms include diarrhea or weight loss [1]. The most common site of involvement is the small intestine especially the jejunum with some cases reported in the stomach as well [2]. We are reporting a case of an unfortunate 53-year-old Caucasian gentleman who initially presented for urinary tract infection and was incidentally found to have abdominal wall thickening on the CT scan which turned out to be MEITL.…”

Section: Introductionmentioning

confidence: 98%

“…It has been described as more common in the Asian and rare in the western population. It occurs over a wide age range with a median age of 58 years and with a male to female ratio of 2:1 [2]. The most common presentation is intestinal perforation or obstruction, and this was described in more than half of the patients.…”

Section: Introductionmentioning

confidence: 99%

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Incidental Diagnosis of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Case Report

Gopalakrishna

Al‐Abdouh

Nair

et al. 2020

Cureus

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Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare, rapidly progressive, primary intestinal T-cell lymphoma. It is most commonly seen in the Asian and Hispanic populations and is usually not related to celiac disease, unlike type I enteropathy associated Tcell lymphoma. The most common site of occurrence is the small intestine. Patients usually present during the advanced stage of disease with clinical features of intestinal perforation or obstruction. The late clinical presentation and lack of targeted therapy are factors contributing to its poor prognosis. Here, we are presenting the case of a patient who initially came to the hospital for a urinary tract infection. As his abdominal CT scan showed abdominal wall thickening, he underwent further workup which revealed the diagnosis of MEITL.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incidental Diagnosis of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Case Report

Gopalakrishna

Al‐Abdouh

Nair

et al. 2020

Cureus

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“…Primary GI tract lymphomas are mainly composed of B-cell neoplasia, which involve the whole GI tract, including the colorectum [3]. T/natural killer (NK)-cell lymphoma (TNKCL) of the GI tract has occasionally been reported [4,5]. Enteropathy-associated T-cell lymphoma (EATL) frequently occurs in Europe and the United States, and consists of CD3+, CD30+/−, CD56 − lymphoma cells, which are closely associated with celiac disease [6].…”

Section: Introductionmentioning

confidence: 99%

Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma

Ishibashi

Nimura

Hirai

et al. 2020

Preprint

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Background Colorectal T/NK cell lymphomas (TNKCL) were very rare. Endoscopic and clinicopathological characteristics of colorectal TNKCL have not been clearly demonstrated. In this study, we demonstrated the clinical characteristics of colorectal TNKCL.Methods Endoscopic and clinicopathological characteristics were investigated in 27 patients with colorectal monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), adult T-cell leukemia/lymphoma (ATLL), and other types of TNKCL.Results Nine TNKCL patients (33%) were classified as MEITL, 11 (41%) as ATLL, and seven (26%) as other. Four Epstein-Barr Virus (EBV) + TNKCL patients were categorized as other. Endoscopically, six MEITL (67%) and five ATLL (46%) showed diffuse-infiltrating type, in which the main endoscopic lesion was edematous mucosa in MEITL, while aphthoid erosion and edematous mucosa were typical in ATLL. Ulcerative type was identified in four other group patients (57%), including two EBV + TNKCL. More than two colorectal lymphomatous lesions were found in seven MEITL (78%) compared with one other group patient (14%) (P < 0.05). An increase in atypical T-intraepithelial lymphocytes (T-IELs) was noted in seven MEITL (88%) and six ATLL (60%) patients, but no other group (0%) patients. Five MEITL patients (56%) showed features of lymphocytic proctocolitis with increased CD8 + T-IELs.Conclusions MEITL and ATLL occasionally invaded the colorectum, and primary involving MEITL was observed. Diffuse infiltrating type was the characteristic endoscopic finding in colorectal MEITL and ATLL, and ulcerative type was observed in the other group. Features of lymphocytic proctocolitis may be prodromal findings of MEITL.

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Aggressive T‐cell lymphomas: 2021 Updates on diagnosis, risk stratification and management

Zain

Hanona²

2021

American J Hematol

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Introduction: Aggressive T-cell lymphomas continue to have a poor prognosis. There are over 27 different subtypes of peripheral T-cell lymphoma (PTCL), and we are now beginning to understand the differences between the various subtypes beyond histologic variations. Molecular Pathogenesis of Various Subtypes of PTCL: Gene expression profiling (GEP) can help in diagnosis and prognostication of various subtypes including PTCLnos and anaplastic large cell lymphoma (ALCL). In addition, mutational analysis is now being incorporated in clinical trials of novel agents to evaluate various biomarkers of response to allow better therapeutic choices for patients. Targeted Therapies: There are many targeted agents currently in various stages of clinical trials for PTCL that take advantage of the differential expression of specific proteins or receptors in PTCL tumors. This includes the CD30 directed antibody drug conjugate brentuximab vedotin. Other notable targets are CD25, CCR4, inhibition of PI3kinasem TOR and JAK/STAT pathways. The ALK inhibitors are promising for ALK expressing tumors. Immunotherapies: Allogeneic stem cell transplant continues to be the curative therapy for most aggressive subtypes of PTCL. The use of checkpoint inhibitors in the treatment of PTCL is still controversial. The most promising results have been seen in cases of extranodal natural killer cell/T-cell (ENK/T) lymphomas and cutaneous T-cell lymphomas (CTCL). Bispecific antibody based treatments as well as CAR-T cell based therapies are in clinical trials.

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T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update

Cited by 74 publications

References 95 publications

Incidental Diagnosis of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Case Report

Incidental Diagnosis of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Case Report

Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma

Aggressive T‐cell lymphomas: 2021 Updates on diagnosis, risk stratification and management

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