T‐ and B‐cell clonally restricted pseudolymphoma in the setting of phytoestrogen therapy

Drug‐associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction

“…A topical estrogen patch has not been previously implicated in the evolution of drug‐associated pseudolymphoma. However, we recently reported a role for phytoestrogens in the evolution of an intraoral pseudolymphoma with both T and B‐cell clonality; we showed a reduction in T lymphocytic proliferative responses when the phytoestrogen at pharmacological concentration was added to lymphocyte cultures 25 …”

“…However, we recently reported a role for phytoestrogens in the evolution of an intraoral pseudolymphoma with both T and B-cell clonality; we showed a reduction in T lymphocytic proliferative responses when the phytoestrogen at pharmacological concentration was added to lymphocyte cultures. 25 We use the designation of reversible granulomatous T-cell dyscrasia to emphasize the resemblance of these lesions to MF based not on light microscopic features but phenotypic and molecular characteristics that closely simulate MF. The biopsies in our cases showed significant losses of one or both of CD7 and CD62L and, in one case, of CD5.…”