T-2 toxin and its cardiotoxicity: New insights on the molecular mechanisms and therapeutic implications

Dai, Chongshan; Gupta, S.; Wang, Zhanhui; Jiang, Haiyang; Velkov, Tony; Shen, Jianzhong

doi:10.1016/j.fct.2022.113262

Cited by 15 publications

(7 citation statements)

References 146 publications

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“…DON, which has immune toxicity, oxidative damage, haptoral and renal toxicity, and reproductive toxicity, was mainly detected in barley grains, chicken, eggs, feed, and wheat [ 82 , 83 , 84 ]. T-2 toxin, which causes various cardiovascular diseases, was detected in drinking water and Chinese herbal medicine [ 85 ].…”

Section: Applications In Food Safety Detectionmentioning

confidence: 99%

Recent Advances in Fluorescent Nanoprobes for Food Safety Detection

Yuan

et al. 2023

Molecules

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Fluorescent nanoprobes show similar fluorescence properties to traditional organic dyes, but the addition of nanotechnology accurately controls the size, shape, chemical composition, and surface chemistry of the nanoprobes with unique characteristics and properties, such as bright luminescence, high photostability, and strong biocompatibility. For example, modifying aptamers or antibodies on a fluorescent nanoprobe provides high selectivity and specificity for different objects to be tested. Fluorescence intensity, life, and other parameters of targets can be changed by different sensing mechanisms based on the unique structural and optical characteristics of fluorescent nanoprobes. What’s more, the detection of fluorescent nanoprobes is cost-saving, simple, and offers great advantages in rapid food detection. Sensing mechanisms of fluorescent nanoprobes were introduced in this paper, focusing on the application progress in pesticide residues, veterinary drug residues, heavy metals, microbes, mycotoxins, and other substances in food safety detection in recent years. A brief outlook for future development was provided as well.

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Section: Applications In Food Safety Detectionmentioning

confidence: 99%

Recent Advances in Fluorescent Nanoprobes for Food Safety Detection

Yuan

et al. 2023

Molecules

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“…Mycotoxins most frequently encountered are ochratoxin, aflatoxins, zearalenone, deoxynivalenol, and fumonisin [ 2 , 3 ]. Their adverse effects are manifold and include reproductive toxicity, immunological toxicity, genetic toxicity, hepatorenal toxicity, and cardiac toxicity [ 4 , 5 , 6 ]. Aflatoxins (AFs) are highly toxic mycotoxins synthesized primarily by filamentous fungi such as Aspergillus flavus , Aspergillus nomius , and Aspergillus parasiticus [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Detoxification of Aflatoxin B1 by Enterococcus faecium HB2-2

Feng,

Cao,

et al. 2024

Foods

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Aflatoxin B1 (AFB1) contamination in food and feed is a global health and economic threat, necessitating the immediate development of effective strategies to mitigate its negative effects. This study focuses on the isolation and characterization of Enterococcus faecium HB2-2 (E. faecium HB2-2) as a potent AFB1-degrading microorganism, using morphological observation, biochemical profiling, and 16S rRNA sequence analysis. An incubation of E. faecium HB2-2 at 32 °C for 96 h in a pH 10 nutrient broth (NB) medium resulted in a remarkable degradation rate of 90.0% for AFB1. Furthermore, E. faecium HB2-2 demonstrated 82.9% AFB1 degradation rate in the peanut meal, reducing AFB1 levels from 105.1 to 17.9 μg/kg. The AFB1 degradation ability of E. faecium HB2-2 was found to be dependent on the fermentation supernatant. The products of AFB1 degradation by E. faecium HB2-2 were analyzed by liquid chromatography–mass spectrometry (LC-MS), and a possible degradation mechanism was proposed based on the identified degradation products. Additionally, cytotoxicity assays revealed a significant reduction in the toxicity of the degradation products compared to the parent AFB1. These findings highlight the potential of E. faecium HB2-2 as a safe and effective method for mitigating AFB1 contamination in food and feed.

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“…Among these, the most commonly encountered mycotoxins are ochratoxin A (OTA), aflatoxins, zearalenone (ZEN), deoxynivalenol (DON), and fumonisins ( Karlovsky et al., 2016 ). The harmful effects of mycotoxins are numerous and include reproductive toxicity, immunotoxicity, genetic toxicity, hepatorenal toxicity, and cardiac toxicity ( Dai et al., 2022a ; L. Li et al., 2021 ; Pleadin et al., 2019 ; Sun et al., 2022 ; Ulger et al., 2020 ). In addition, mycotoxin exposure is closely related to the occurrence of cancer ( Cao et al., 2022 ; Singh et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms by which microbial enzymes degrade four mycotoxins and application in animal production: A review

Sun,

He,

Xiong

et al. 2023

Animal Nutrition

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T-2 toxin and its cardiotoxicity: New insights on the molecular mechanisms and therapeutic implications

Cited by 15 publications

References 146 publications

Recent Advances in Fluorescent Nanoprobes for Food Safety Detection

Recent Advances in Fluorescent Nanoprobes for Food Safety Detection

Biological Detoxification of Aflatoxin B1 by Enterococcus faecium HB2-2

Mechanisms by which microbial enzymes degrade four mycotoxins and application in animal production: A review

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