t(14;18)(q32;q21) involving <i>IGH</i> and <i>MALT1</i> is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B‐cell lymphomas

Wongchaowart, Nicholas; Kim, Bong Keun; Hsi, Eric D.; Swerdlow, Steven H.; Tubbs, Raymond R.; Cook, James R.

doi:10.1111/j.0303-6987.2006.00459.x

Cited by 33 publications

(19 citation statements)

References 26 publications

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“…83 MALT-lymphoma associated translocations have not been described. 81,84,85 but clonality can usually be shown by PCR. 75,76 PCMZL is an indolent disease with a 5-year disease-specific survival of over 95%.…”

Section: Primary Cutaneous Marginal Zone Lymphomamentioning

confidence: 99%

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

et al. 2014

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Section: Primary Cutaneous Marginal Zone Lymphomamentioning

confidence: 99%

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

et al. 2014

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“…About 5% of intestinal and pulmonary MZBCLs harbor the t(1;14) ( Table 2). [128][129][130][131]142,143 More recently, three novel IgH translocations in non-gastric MZBCL involving ODZ2, CNN3 and JMJD2C have been described, of which ODZ2 and JMJD2C were found recurrently. 144 The t(11;18) is present in ~40% of pulmonary-and iñ 20% of gastric-MZBCLs and is virtually absent in MZBCLs of the salivary gland (Table 2).…”

Section: Genetic Alterations In Low-and High-grade Extranodal Marginamentioning

confidence: 99%

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

Bende¹,

Maldegem²,

Noesel³

2009

Haematologica

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Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.Key words: B-cell non-Hodgkin's lymphoma, extranodal marginal zone B-cell lymphoma, immunoglobulin, B-cell antigen receptor, inflammation, lymphoid tissue neogenesis. Haematologica 2009;94:1109-1123. doi:10.3324/haematol.2009 This is an open-access paper. Citation: Bende RJ, van Maldegem F, and van Noesel CJM. Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B cell lymphomas. ABSTRACT Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

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“…Streubel et al 12 reported API2-MALT1 translocation in 4 of 51 cases, but others, including the cases reported here, did not detect any cases with this abnormality. 9,11,[13][14][15][16] The IGH-MALT1 translocation has been reported in 7/51 cases 12 and 3/12 cases. 15 However, it was absent in several other studies.…”

Section: Primary Cutaneous Marginal Zone B-cell Lymphoma H Takino Et Almentioning

confidence: 98%

“…15 However, it was absent in several other studies. 13,14 The explanation for these variable results remains unknown. In MALT lymphomas, an association between nuclear BCL10 expression and the presence of API2-MALT1 fusion has been suggested.…”

Section: Primary Cutaneous Marginal Zone B-cell Lymphoma H Takino Et Almentioning

confidence: 99%

“…8,9 API2-MALT1 fusion, resulting from t(11;18) (q21;q21) is specific to MALT lymphoma, and has been found in 10-20% of gastric cases and in up to 50% of pulmonary cases, but is rare in autoimmuneassociated cases. 10 This gene alteration has been reported in 0-7.8% of cutaneous marginal zone B-cell lymphomas, 9,[11][12][13][14][15][16] but overall its frequency is not clear.…”

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Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States

Takino

et al. 2008

Modern Pathology

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Primary cutaneous marginal zone B-cell lymphoma is considered the cutaneous counterpart of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Although its molecular pathogenesis is currently unknown, an etiological link with Borrelia burgdorferi infection has been identified in European, but not in American or Asian cases. To better understand the pathogenesis and the geographical differences of cutaneous marginal zone B-cell lymphoma, 60 cases from the East Asia, Germany, and the United States at their initial presentation were subjected to the following analyses; (1) clinicopathological comparison between the geographical regions, (2) detection of B. burgdorferi DNA, (3) detection of the API2-MALT1 fusion transcript, a gene alteration specific to mucosa-associated lymphoid tissue lymphoma, and (4) inactivation of tumor suppressor genes (death-associated protein kinase (DAPK), p16 INK4a , p14 ARF , MGMT, TIMP3, CDH1, and RARB) by hypermethylation of the CpG islands. Cases from the three geographical regions showed similar clinicopathological features. However, moderate/marked tissue eosinophilia was found in 9/25 Asian cases, but only 1/23 German cases (P ¼ 0.011) and 0/12 American cases (P ¼ 0.015). All 60 cases were negative for either Borrelia DNA or API2-MALT1 fusion. Tumors from the three regions were highly methylated for DAPK (38-50% of the cases, mean 43%) and p16 INK4a (42-70%, mean 49%), and the positivities were significantly higher than those of nonneoplastic skin (8%, P ¼ 0.0010 and 14%, P ¼ 0.0032, respectively). Methylation of these genes had no significant association with progressive features of the tumor. Primary cutaneous marginal zone B-cell lymphomas from the three geographical regions have common clinicopathological features, however, moderate/marked tissue eosinophilia is a feature found almost exclusively in Asian cases. Borrelia infection and API2-MALT1 fusion are not significant in this tumor. Methylation of DAPK and p16 INK4a genes is a frequent event in this lymphoma at its initial presentation, but may not be associated with tumor progression.

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t(14;18)(q32;q21) involving IGH and MALT1 is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B‐cell lymphomas

Cited by 33 publications

References 26 publications

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States

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