t(12:21) is Underrepresented in Childhood B-lineage Acute Lymphoblastic Leukemia in Punjab, Pakistan

Faiz, Mariam; Qazi, Javed Iqbal

doi:10.1097/mph.0b013e3181c9af65

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Previously, the prevalence of TEL-AML1 fusion oncogene in Pakistani population has been reported by to be 11% (Iqbal and Tanveer, 2006) which is in accordance with our findings, although that study lacked clinical outcome of TEL-AML1 positive patients. In another study from Lahore, Punjab, Pakistan, 6% (3/50) frequency of TEL-AML1 has been reported (Faiz and Qazi., 2010), while others have reported frequency of this gene to be to be about 16% (Iqbal et al, 2007;Awan et al, 2012). However, all of these studies were carried out at single centre or locations in Pakistan and does not represent a major subset of childhood ALL population of the country.…”

Section: Discussionmentioning

confidence: 96%

“…Although, global frequency of TEL-AML1 positivity has been reported to be 20-30% in pediatric ALL (Hong et al, 2008), some authors have reported very lower frequencies of TEL-AML1in some geographical regions (Kwong and Wong, 1997;Eguchi-Ishimae et al, 1998;Garcia-Sanz et al, 1999;Tsang et al, 2001;Rahman et al, 2006;Chung et al, 2010;Mazloumi et al, 2012) including one study from a single centre at Lahore, Punjab, Pakistan indicating 6% (3/50) frequency of TEL-AML1 (Faiz and Qazi, 2010), while others have reported frequency of this gene to be at other single Centres to be about 16% (Iqbal et al, 2007;Sabir et al, 2012). However, all of these studies were carried out at single centre or locations in Pakistan and therefore does not provide a comprehensive view of TEL-AML1 frequency in Pakistani population.…”

Section: Molecular Genetic Studies On 167 Pediatric All Patients Frommentioning

confidence: 99%

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Molecular Genetic Studies on 167 Pediatric ALL Patients from Different Areas of Pakistan Confirm a Low Frequency of the Favorable Prognosis Fusion Oncogene TEL-AML1 (t 12; 21) in Underdeveloped Countries of the Region

Iqbal

2014

Asian Pacific Journal of Cancer Prevention

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TEL-AML1 fusion oncogene (t 12; 21) is the most common chromosomal abnormality in childhood acute lymphoblastic leukemia (ALL). This translocation is associated with a good prognosis and rarely shows chemotherapeutic resistance to 3-drug based remission induction phase of treatment as well as overall treatment. Thus, the higher the frequency of this fusion oncogene, the easier to manage childhood ALL in a given region with less intensive chemotherapy. Although global frequency of TEL-AML1 has been reported to be 20-30%, a very low frequency has been found in some geographical regions, including one study from Lahore, Punjab, Pakistan and others from India. The objective of present study was to investigate if this low frequency of TEL-AML1 in pediatric ALL is only in Lahore region or similar situation exists at other representative oncology centers of Pakistan. A total of 167 pediatric ALL patients were recruited from major pediatric oncology centers situated in Lahore, Faisalabad, Peshawar and Islamabad. Patients were tested for TEL-AML1 using nested reverse transcription polymerase chain reaction (RT-PCR). Only 17 out of 167 (10.2%) patients were found to be TEL-AML1 positive. TEL-AML1+ALL patients had favorable prognosis, most of them (82.4%, 14/17) showing early remission and good overall survival. Thus, our findings indicate an overall low frequency of TEL-AML1 in Pakistan pediatric ALL patients, in accordance with lower representation of this prognostically important genetic abnormality in other less developed countries, specifically in south Asia, thus associating it with poor living standards in these ethnic groups. It also indicates ethnic and geographical differences in the distribution of this prognostically important genetic abnormality among childhood ALL patients, which may have a significant bearing on ALL management strategies in different parts of the world.

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Section: Discussionmentioning

confidence: 96%

Section: Molecular Genetic Studies On 167 Pediatric All Patients Frommentioning

confidence: 99%

Molecular Genetic Studies on 167 Pediatric ALL Patients from Different Areas of Pakistan Confirm a Low Frequency of the Favorable Prognosis Fusion Oncogene TEL-AML1 (t 12; 21) in Underdeveloped Countries of the Region

Iqbal

2014

Asian Pacific Journal of Cancer Prevention

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“…Faiz and Qazi also reported a less than expected favourable translocation t (12; 21) in Pakistani population. [18,19] However, even the highest estimates place the adverse cytogenetics group around 7-8%, which would still mean that over 90% of children could possibly be stratified to receive a lower intensity treatment. The importance of risk stratification is thus highlighted based on conventional, molecular and cytogenetic criteria to avoid over or under treatment.…”

Section: Discussionmentioning

confidence: 99%

High Infection Related Mortality in Pakistani Children With Acute Lymphoblastic Leukaemia During Remission Induction Chemotherapy: Review of Data From a Single Institution

Maaz

Badar

Mahmood

et al. 2016

J Cancer Allied Spec

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Purpose: Despite advances in the treatment of acute lymphoblastic leukaemia (A.L.L.), the outcome for children living in the developing countries is still poor. This is in large part due to high treatment-related mortality (TRM). This study was carried out to review the data and analyze the factors resulting in high TRM during remission induction chemotherapy. Methods: Data for children treated at our centre during the calendar year 2007 were retrospectively analysed. Standard four-drug induction chemotherapy was used without risk strati cation. Bone marrow evaluation was carried out at days 8 and 28. Cerebrospinal uid analysis was carried out on day 1 and with each subsequent intrathecal chemotherapy injection. Modern supportive care facilities including antibiotics, nutritional support and intensive care unit were available. Results: Eighty-one children were eligible for analysis. Median age was 5 years (range 2–16), 72% were male with M:F ratio of 2.5:1. Seventy- five (92%) children had precursor B-cell A.L.L. Only 2 children had central nervous system leukaemia at presentation. Median presenting white blood cell count was 8.83 (range: 1–446). Severe malnutrition (weight <5th centile for age) was seen in 42% of children. Median symptom duration was 6 (range 1–30) weeks at the time of presentation. Induction mortality was 25%. Induction mortality was 25.6% (n = 21). Twenty were related to infections, while more than half (52%) occurred as a result of an outbreak of Acinetobacter infection. Severe malnutrition and Acinetobacter infection (due to an outbreak in our unit during the study period) were highly predictive of TRM during remission induction chemotherapy. Conclusions: Infection control measures, health education and reduction in treatment intensity may improve survival for children with A.L.L. in Pakistani population. Key words: Acute lymphoblastic leukaemia in children, malnutrition, Pakistan, treatment-related mortality

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Frequency of Three Different Gene Mutations (TEL-AML1, E2A-PBX1 and MLL-AF4) In Acute Lymphoblastic Leukaemia

Khan¹

2016

HTIJ

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t(12:21) is Underrepresented in Childhood B-lineage Acute Lymphoblastic Leukemia in Punjab, Pakistan

Cited by 4 publications

References 13 publications

Molecular Genetic Studies on 167 Pediatric ALL Patients from Different Areas of Pakistan Confirm a Low Frequency of the Favorable Prognosis Fusion Oncogene TEL-AML1 (t 12; 21) in Underdeveloped Countries of the Region

Molecular Genetic Studies on 167 Pediatric ALL Patients from Different Areas of Pakistan Confirm a Low Frequency of the Favorable Prognosis Fusion Oncogene TEL-AML1 (t 12; 21) in Underdeveloped Countries of the Region

High Infection Related Mortality in Pakistani Children With Acute Lymphoblastic Leukaemia During Remission Induction Chemotherapy: Review of Data From a Single Institution

Frequency of Three Different Gene Mutations (TEL-AML1, E2A-PBX1 and MLL-AF4) In Acute Lymphoblastic Leukaemia

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