Systolic Ventricular Function

Mertens, Luc; Friedberg, Mark K.

doi:10.1002/9781118742440.ch7

Cited by 10 publications

(9 citation statements)

References 143 publications

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“…While normal values of FAC in adults have been reported as ≥32-35% 17,18 , normal values have not previously been reported in children. Our determined normal value of ≥ 34% is in keeping with the adult literature and not as strict as the previously asserted pediatric value 3 . We have shown that while FAC in transplant patients is on average lower than controls, the majority of patients have FAC values in the normal range.…”

Section: Discussionsupporting

confidence: 87%

“…Common quantitative metrics for assessment of RV function include tricuspid annular plane systolic excursion (TAPSE, a measure of longitudinal RV contraction), fractional area change (FAC, a metric which incorporates both longitudinal motion of the annulus and motion of the RV free wall), and the peak systolic annular velocity of the lateral tricuspid annulus (S') 3 . These methods have geometric limitations, in particular difficulties in visualization of the endocardial border of the RV free wall 4 .…”

Section: Introductionmentioning

confidence: 99%

“…While there are existing studies assessing healthy control values for TAPSE 5 and S' 6 , normal values for FAC in children have not been established 4 . A value of ≥40% has been suggested, but not validated, in children 3 . Furthermore, the expected values of these quantitative metrics in the pediatric heart transplant population have never to our knowledge been fully assessed in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Echocardiographic Assessment of Right Ventricular Function in Clinically Well Pediatric Heart Transplantation Patients and Comparison With Normal Control Subjects

White

Katcoff

Faerber

et al. 2019

Journal of the American Society of Echocardiography

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Background-Echocardiographic follow-up after pediatric heart transplantation is important due to the lifelong risk of rejection and resultant ventricular dysfunction. While adult studies have shown that echocardiographic measures of right ventricular (RV) function are changed after transplantation, similar results have not been reported in the pediatric population. Methods-We performed a single-center retrospective study of echocardiograms performed in pediatric heart transplant recipients. All echocardiograms were selected remote from transplantation, rejection, or graft vasculopathy. These criteria identified 127 patients. RV systolic function was measured with tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and peak systolic tricuspid annular tissue velocity (S'). Results were compared to 380 healthy age-matched echocardiographic controls. Results-TAPSE values in pediatric heart transplant recipients were significantly lower than controls at all ages (p<0.0001) with a mean Z-score of −3.38. FAC and S' did not vary by age in control patients above 6 months old. FAC values in transplant patients were significantly decreased compared to controls (p<0.0001), but 83% of transplant patients had FACs within the controlderived normal range. S' values were also significantly lower for transplants than controls (p<0.0001). Conclusion-Heart transplant patients have significantly decreased quantitative metrics of RV function relative to healthy controls; longitudinal shortening (TAPSE and S') is particularly affected. FAC is relatively preserved and may be a better metric in this population. These results *

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Echocardiographic Assessment of Right Ventricular Function in Clinically Well Pediatric Heart Transplantation Patients and Comparison With Normal Control Subjects

White

Katcoff

Faerber

et al. 2019

Journal of the American Society of Echocardiography

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“…16 Left ventricular ejection fraction (LVEF) was a change in the volume of the left ventricle from the end of the diastolic phase to the end of the systolic phase. 17 Normal EF values were considered to be 56-78%. 18 Fractional shortening (FS) was the percentage change in the dimensions of the left ventricular cavity during systolic contraction and was a parameter often used to express systolic function.…”

Section: Methodsmentioning

confidence: 99%

Troponin-I and left ventricular function in pediatric high-risk acute lymphoblastic leukemia after daunorubicin treatment

Annur

Hariyant

Izzah

2021

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Background Daunorubicin is a chemotherapy drug for leukemia treatment, but it can cause cardiotoxicity. When heart damage occurs, myocardial sarcomeres release troponin-I, which could potentially be useful as a cardiotoxicity biomarker. Objective To assess for possible correlations between troponin-I and echocardiographic parameters of left ventricular function after administration of daunorubicin in children with high-risk acute lymphoblastic leukemia (ALL). Methods This cross-sectional study on 37 children with high-risk ALL was performed from July 2017 to December 2018, in Padang, West Sumatera. The left ventricular systolic function parameters measured were ejection fraction (EF) and fractional shortening (FS); the left ventricular diastolic function parameter was E/A ratio. Troponin-I measurements and echocardiography were performed after daunorubicin treatment at the end of induction phase chemotherapy. Pearson’s correlation test was used to analyze for a correlation between troponin-I and echocardiographic parameters. Results Subjects had a mean age of 6.27 (SD 4.43) years, and males comprised 56.8%. Subjects’ mean troponin-I concentration was 5.49 (SD 0.86) ng/mL, and mean EF, FS, and E/A values were 65 (SD 5) %, 36 (SD 4) %, and 1.52 (SD 0.56), respectively. Troponin-I was not significantly correlated with EF (r=0.062; P=0.715) or FS (r=0.309; P=0.172). However, there was a weak, significant negative correlation between troponin-I and E/A ratio (r=-0.383; P=0.019). Conclusion Troponin-I level has no significant correlations with the echocardiographic parameters of left ventricular systolic function. However, there is a weak significant negative correlation between troponin-I level and the left ventricular diastolic parameter of E/A ratio.

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“…Assessment of pulmonary artery pressure: The tricuspid regurgitant (TR) jet is used to estimate pulmonary artery pressure, and represents the most common and reliable method to evaluate for the presence and severity of PH [11]. Also assessment for flattening of interventricular septum and accelerated pulmonary regurgitation velocity, by continuous-wave doppler using the modified Bernoulli equation in the absence of RV outflow tract (RVOT) obstruction to determine the RV systolic pressure (RVSP) which is the same systolic pulmonary artery pressure (SPAP)RVSP = SPAP = 4(TR max)2 + mean RA pressure (mRAP).…”

Section: Methodsmentioning

confidence: 99%

Plasma Asymmetric Dimethylarginine Levels in Neonates with Bronchopulmonary Dysplasia Associated with Pulmonary Hypertension

Meneza¹,

Bahgat²,

Nasr³

2018

OJPed

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Background: Bronchopulmonary dysplasia (BPD) continues to be an important problem in neonates especially premature infants despite improved facilities of care, monitoring and treatment. Pulmonary hypertension (PH) is a major complicating factor and key cause of mortality in this population. Altered vascular and alveolar growth particularly in canalicular and early saccular stages of lung development following mechanical ventilation and oxygen therapy result in arrest of the lung development leading to BPD with PH. Early recognition of PH in infants with these risk factors is important for optimal management. We tested the hypothesis that asymmetric dimethylarginine, would be greater in infants with bronchopulmonary dysplasia associated pulmonary hypertension than in infants with BPD alone. The Aim: The aim of the current study was to measure the Asymmetric dimethylarginine (ADMA) levels, arginine levels & the plasma arginine-to-ADMA ratio in newborn infants with broncho-pulmonary dysplasia, to evaluate echocardiographic parameters among neonates with bronchopulmonary dysplasia, to correlate between plasma ADMA & arginine-to-ADMA ratio and echocardiographic (ECHO) parameters in those patients and to compare full term & preterm neonates with bronchopulmonary dysplasia as regard to plasma ADMA level. Methods: A case-control study was carried out of ninety (90) newborns selected from those admitted to Neonatal Intensive Care Unit at Maternity & Children Hospital and Alzhraa University hospital during the period from October 2015 to March 2018. Neonates were divided into 2 groups: Patient with BPD with PH (cases group): It included 45 neonates with BPD & PH, 35 preterm neonates and 10 full term neonates. Patient with BPD only (Control group): It included 45 neonates with BPD without PH. These 45 neonates were divided as 22 preterm neonates and 23 full term neonates.

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Systolic Ventricular Function

Cited by 10 publications

References 143 publications

Echocardiographic Assessment of Right Ventricular Function in Clinically Well Pediatric Heart Transplantation Patients and Comparison With Normal Control Subjects

Echocardiographic Assessment of Right Ventricular Function in Clinically Well Pediatric Heart Transplantation Patients and Comparison With Normal Control Subjects

Troponin-I and left ventricular function in pediatric high-risk acute lymphoblastic leukemia after daunorubicin treatment

Plasma Asymmetric Dimethylarginine Levels in Neonates with Bronchopulmonary Dysplasia Associated with Pulmonary Hypertension

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