Systolic time intervals as a measure of left ventricular function in viscose rayon workers exposed to carbon disulfide.

Abstract

Systolic time intervals as a measure of left ventricular function in viscose rayon workers exposed to carbon disulfide. by Franco G, Malamani T In a group of viscose rayon workers exposed to carbon disulfide the systolic time intervals were calculated. They were determined from the simultaneous recording of an ECG, a phonocardiogram, and arterial pulse tracings. Results indicate a shortened left ventricular ejection time (LVET) and a prolonged isovolumetric contraction time (ICT), together with an increase in the ratio of ICT to LVET. These alterations, which occurred in the absence of any clinical signs or symptoms of heart disease, are interpreted as a consequence of an impaired left ventricular contractility, comparable to mild coronary dysfunction. Literature data support the hypothesis that the biochemical mechanisms involved in the effect of carbon disulfide on myocardial cells are (a) an interference with energy metabolism from the inadequate availability of thiamine and nicotinamide or a direct inhibition of cytochrome or (b) an interference with catecholamine metabolism and defective hormonal control of the energy utilization process. Impaired left ventricular function in rayon viscose workers exposed to carbon disulfide represents an early and highly sensitive sign of carbon disulfide intoxication, and the use of systolic time intervals as a noninvasive measure of myocardial performance may be a useful method for monitoring carbon disulfide exposed people.

Assessment of coronary heart disease risk among viscose rayon workers exposed to carbon disulfide at concentrations of about 30 mg/m3.

“…In fact alterations of 118 some systolic time intervals, in the absence of any clinical symptom of heart disease, have been observed in CS 2 -exposed workers (9,37). These alterations, comparable to mild CHD dysfunction, were interpreted as a consequence of an impaired left ventricular contractility.…”

“…Furthermore a higher incidence of angina (31), an increased prevalence of coronary electrocardiographic findings (2,7,13,31), and impaired left ventricular 0355-3140/82/020113-08USD3.00 contractility compatible with mild coronary dysfunction (9,37) have also been found in some studies. However, a joint Finnish-Japanese survey did not reveal any increased prevalence of angina or electrocardiographic findings in Japanese viscose rayon workers, whereas among Finnish workers the eS 2 exposure was associated with an excess of angina and a slightly higher blood pressure (30).…”

Cardiovascular Toxicology

“…These cardiac responses were not present in the control group. Franco et al measured ECG changes in viscose rayon workers exposed to carbon disulfide concentrations below the threshold limit value of 60 mg/m 3 at the time (525). Exposure history of 31 to 57 ppm-year of carbon disulfide was associated with an OR of 7.2 (95% CI ¼ 1.5-36.7).…”

Cerebellar Atrophy as a Delayed Manifestation of Chronic Carbon Disulfide Poisoning.

“…Personal exposure data are not available. During the '70s, measured CS 2 air levels from the factory ranged from 10 to 60 mg/m 3 (3-19 ppm) 9) . The patient occasionally abused of alcoholic beverages and was a lifelong smoker (10-20 cigarettes/day).…”