Systolic Function Reserve Using Two-Dimensional Strain Imaging in Hypertrophic Cardiomyopathy: Comparison with Essential Hypertension

Badran, Hala Mahfouz; Faheem, Naglaa; Ibrahim, Waleed; Elnoamany, Mohamed Fahmy; Elsedi, Mohamed; Yacoub, Magdi H.

doi:10.1016/j.echo.2013.08.026

Cited by 32 publications

(21 citation statements)

References 34 publications

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“…The position allows robust and reproducible analysis dedicated to echocardiography. Moreover, the average exercise LVOT gradients obtained here are close to those obtained by Maron et al 3 We did not perform exercise strain analysis, as others have proposed, 29,30 because the reproducibility of high heart rate measurements could be questionable.…”

Section: Value Of Exercise Echocardiographic Evaluation In Hcmsupporting

confidence: 85%

Comparison of Resting and Exercise Echocardiographic Parameters as Indicators of Outcomes in Hypertrophic Cardiomyopathy

Réant

Reynaud

Pillois

et al. 2015

Journal of the American Society of Echocardiography

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Section: Value Of Exercise Echocardiographic Evaluation In Hcmsupporting

confidence: 85%

Comparison of Resting and Exercise Echocardiographic Parameters as Indicators of Outcomes in Hypertrophic Cardiomyopathy

Réant

Reynaud

Pillois

et al. 2015

Journal of the American Society of Echocardiography

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“…Exercise capacity was evaluated by metabolic equivalents (METs). Any subject who achieved METs <7 was defined as having a reduced exercise capacity . Maximal HR, peak systolic blood pressure (SBP), METs, and peak rate‐pressure product (RPP = maximal HR × SBP) were recorded at peak exercise.…”

Section: Methodsmentioning

confidence: 99%

Impaired left ventricular mechanics and functional reserve are associated with reduced exercise capacity in patients with hypertrophic cardiomyopathy

Zhang

et al. 2019

Echocardiography

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Background: Reduced metabolic equivalents (METs) are an indicator of exercise intolerance, which predicts poor prognosis in hypertrophic cardiomyopathy (HCM) patients. We sought to evaluate the changes in left ventricular (LV) mechanics and functional reserves, as well as their association with functional capacity in HCM patients.Methods: Seventy HCM patients and thirty controls were included in this study. LV mechanics were evaluated at rest and during exercise by echocardiography and twodimensional speckle-tracking imaging to obtain parameters of functional reserve, LV global longitudinal strain (LVGLS), strain rate (SR), and circumferential strain.Results: Hypertrophic cardiomyopathy (HCM) patients had lower LVGLS, systolic SR, early and late diastolic SR at rest and during exercise, and reduced absolute and relative systolic and diastolic reserve compared to controls. LV circumferential strain was significantly higher at rest but lower during exercise in HCM patients. Exercise capacity was markedly reduced in HCM patients, and peak exercise LVGLS (LVGLS-exe) significantly correlated with exercise capacity. Multivariate regression analyses showed that LVGLS-exe, LV filling pressure during exercise (E/e'-exe), and LV mass index (LVMI) were independent predictors of exercise capacity. Moreover, LVGLSexe displayed incremental predictive value over E/e'-exe and LVMI for exercise intolerance. Receiver operating characteristic curve analysis showed LVGLS-exe had optimal accuracy for predicting exercise intolerance in HCM patients. Conclusions:Hypertrophic cardiomyopathy (HCM) patients have reduced LV mechanics at rest and during exercise and impaired mechanical reserve. LVGLS-exe is associated with exercise capacity and is an optimal predictive value for reduced exercise capacity in HCM patients. K E Y W O R D Sexercise stress echocardiography, functional reserve, hypertrophic cardiomyopathy, speckletracking imaging | 267 WU et al.

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“…В отличие от ДКМП пациенты с гипертрофической кардиомиопатией сохраняют амплитуду скручивания неизменной, или она увеличивается [53], тогда как на-правление вращения ЛЖ на уровне папиллярных мышц изменяется от вращения против часовой стрел-ки, наблюдаемого у большинства, к вращению по ча-совой стрелке, сходно с базальными отделами [54]. Из-менения вращения могут указывать как на развитие за-болевания, так и на положительную динамику прово-димой терапии [55].…”

Section: клиническое значение скручивания и рас-кручиванияunclassified

Left Ventricular Rotation, Twist and Untwist: Physiological Role and Clinical Relevance

Pavlyukova

Kuzhel

Matyushin

et al. 2015

Racionalʹnaâ farmakoterapiâ v kardiologii

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ВведениеЗа прошедшие три столетия механическая работа сердца оставалась одним из наиболее интригующих аспектов для физиологов и клиницистов, изучающих этот орган. Еще в 1669 г. было описано уникальное движение скручивания левого желудочка (ЛЖ) [1], физиологи-ческое значение которого становится понятным только сегодня. В попытке исследовать эту важную особенность сердечного сокращения были предложены многочис-ленные методы, такие, как имплантируемые датчики, киноангиография и магнитный резонанс. Однако внед-рение ультразвуковой недопплеровской методики «от-слеживание пятна» (Speckle Tracking Imaging) открыло новые возможности в изучении этой особенности сер-дечного сокращения и сделало его исследование до-ступным в общей клинической практике, в том числе у постели больного. Теория желудочковой мышечной ленты представляет собой новую концепцию, обеспечивающую твердое основание для согласования некоторых важных понятий в сердечно-сосудистой медицине. Спиральная ориентация волокон обеспечивает вращение левого желудочка, которое, вместе с радиальным утолщением и продоль-ным сокращением, предполагается как необходимый компонент эффективной насосной функции левого желудочка. Вращение левого желудочка может быть неин-вазивно оценено в клинической практике с помощью эхокардиографии, что предоставляет новые возможности для оценки различных аспектов механической функ-ции левого желудочка. The helical ventricular myocardial band of Torrent-Guasp is a new concept, which provides strong grounds for reconciliation of some important aspects in cardiovascular medicine. Oblique fiber orientation provides left ventricular rotation, which in addition to radial thickening and longitudinal shortening, is predicted as an essential component of the effective left ventricular pumping. Left ventricular rotation can be measured in clinical practice noninvasively using echocardiography and this provides new opportunities for the assessment of different aspects of left ventricular mechanical function. История изучения скручивания сердца

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Systolic Function Reserve Using Two-Dimensional Strain Imaging in Hypertrophic Cardiomyopathy: Comparison with Essential Hypertension

Cited by 32 publications

References 34 publications

Comparison of Resting and Exercise Echocardiographic Parameters as Indicators of Outcomes in Hypertrophic Cardiomyopathy

Comparison of Resting and Exercise Echocardiographic Parameters as Indicators of Outcomes in Hypertrophic Cardiomyopathy

Impaired left ventricular mechanics and functional reserve are associated with reduced exercise capacity in patients with hypertrophic cardiomyopathy

Left Ventricular Rotation, Twist and Untwist: Physiological Role and Clinical Relevance

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