Systolic blood pressure as a predictor of incident albuminuria and rapid renal function decline in type 2 diabetic patients

Sheen, Yi Jing; Lin, Jiann Liang; Li, Tsai‐Chung; Bau, Cho Tsan; Sheu, Wayne H‐H

doi:10.1016/j.jdiacomp.2014.08.002

Cited by 11 publications

(11 citation statements)

References 54 publications

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“…1). We found that GG-homozygosity was significantly associated with DN in univariate modeling (p = 0.011) and in a multivariate model (OR 6.07 [1.60-22.99], p = 0.008) of clinical factors previously attributed to DN [14,15] (Table 2). Additionally, advanced stages of CKD were independently associated with DN (OR 1.93 [1.15-3.23], p = 0.012).…”

Section: Mmp-9 Rs17576 Snp In Association With Diabetic Nephropathymentioning

confidence: 82%

Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients

Albert

Kube

Albert

et al. 2018

Nephron

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Aim: Aim of this study was to investigate the association of genetic variants of functional polymorphisms of matrix metalloproteinase and Cubilin (CUBN) with diabetic nephropathy (DN), end-stage renal disease (ESRD), and risk of cardiovascular disease (CVD) in Caucasian type 2 diabetes (T2D) patients. Methods: 472 T2D-patients were genotyped for 3 single-nucleotide polymorphisms (SNPs; MMP-2 [rs2285053], MMP-9 [rs17576] and CUBN [rs1801239]). Genotyping was carried out by allelic discrimination using TaqMan SNP-genotyping-assay. Results: MMP-9 (Gln279Arg) AA-genotype (OR 0.17 [0.04–0.62, p = 0.008]) and the time elapsed since diagnosis of T2D without onset of proteinuria (OR 0.87 [0.79–0.97, p = 0.008]) were found to be independently associated with reduced risk of susceptibility to DN. On the contrary higher stages of chronic kidney disease (OR 1.93 [1.15–3.23], p = 0.012) and the presence of MMP-9 GG-genotype were independently associated with DN (OR 6.07 [1.60–22.99], p = 0.008). The CUBN CC or C-risk-allele of rs1801239 was associated with ESRD (OR 2.04 [1.07–3.87], p = 0.03) and peripheral artery disease (OR 2.08 [1.12–3.88], p = 0.021). We could not find an association with MMP-2, MMP-9, or CUBN with CVD in a composite clinical endpoint model. Conclusions: This study highlights that MMP-9 or CUBN-SNPs may exert effects on risk of susceptibility to DN or ESRD. We provide novel evidence on genetic susceptibility for macroangiopathy in patients with a missense variant of CUBN (Ile2984Val) in patients with T2D.

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Section: Mmp-9 Rs17576 Snp In Association With Diabetic Nephropathymentioning

confidence: 82%

Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients

Albert

Kube

Albert

et al. 2018

Nephron

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“…HbA 1c was also established as an independent risk factor for renal impairment in patients with diabetes . It was also shown to be a predictor of early occurrence of doubling of the serum creatinine concentration or of dialysis or renal transplantation in patients with established diabetic nephropathy .…”

Section: Discussionmentioning

confidence: 96%

“…Hypertension is a well‐known risk factor for renal dysfunction in patients with diabetes . SBP reportedly predicts early onset of doubling of the serum creatinine concentration or dialysis or renal transplantation in diabetic patients with nephropathy .…”

Section: Discussionmentioning

confidence: 99%

“…HbA 1c was also established as an independent risk factor for renal impairment in patients with diabetes. 5,13,14 It was also shown to be a predictor of early occurrence of doubling of the serum creatinine concentration or of dialysis or renal transplantation in patients with established diabetic nephropathy. 25 These findings are consistent with our results, suggesting that HbA 1c is a useful marker for predicting the initiation of dialysis as well as renal dysfunction.…”

Section: Figure 1 Shows Spline Curves For the Risk Of Dialysis Accordmentioning

confidence: 99%

“…It is well established that hyperglycaemia and hypertension are two major predictors for development as well as progression of nephropathy in patients with diabetes regardless of its type. [2][3][4][5][6][7][8][9][10][11][12][13][14] Hypertension, commonly recognized as elevated systolic blood pressure (SBP), is an established potent predictor that has an impact equal to or even greater than hyperglycaemia on development and progression of nephropathy. 15 However, little is known about whether these factors are also predictive to the same degree of end-stage renal disease (ESRD), especially in relation to the initiation of dialysis for diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

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Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes

Osawa

Fujihara

Harada

et al. 2019

Diabetes Metabolism Res

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Aims To determine incidence and predictors of starting dialysis in patients with diabetes emphasizing blood pressure variables. Methods A nationwide database with claim data on 18 935 people (15 789 men and 3146 women) with diabetes mellitus aged 19 to 72 years in Japan was used to elucidate predictors for starting dialysis. Initiation of dialysis was determined from claims using ICD‐10 codes and medical procedures. Using multivariate Cox modelling, interactions between glycaemic and blood pressure values were determined. Results During a median follow‐up of 5.3 years, incidence of dialysis was 0.81 per 1000 person‐years. Multivariate analysis of a model involving systolic and diastolic blood pressure (SBP and DBP) simultaneously as covariates showed that hazard ratios (HRs) for starting dialysis for each 1‐SD elevation in SBP and DBP were 2.05 (95% confidence interval 1.58‐2.64) and 0.66 (0.50‐0.88), respectively, implying that pulse pressure (PP) was a promising predictor. For confirmation, a model involving SBP and PP simultaneously as covariates demonstrated that HRs for each 1‐SD elevation in SBP and PP were 1.09 (0.81‐1.48) and 1.54 (1.14‐2.08), respectively, with PP the more potent predictor. Compared with HbA1c <8% and PP <60 mmHg, the HR for those with HbA1c ≥8% and PP ≥60 mmHg was 6.32 (3.42‐11.7). Conclusions In our historical cohort analysis, SBP and PP were independent predictors for starting dialysis. PP was the more potent, suggesting the contribution of increased arterial stiffness to the incidence of dialysis. Future studies are needed to conclude the independent influence of PP and HbA1c on dialysis considering other risk factors.

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The expert consensus on care and education for patients with diabetic kidney disease in Taiwan

Hsu,

Yeh,

Yen

et al. 2024

Primary Care Diabetes

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Systolic blood pressure as a predictor of incident albuminuria and rapid renal function decline in type 2 diabetic patients

Cited by 11 publications

References 54 publications

Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients

Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients

Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes

The expert consensus on care and education for patients with diabetic kidney disease in Taiwan

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