In order to improve business process often Information Technologies (IT) are introduced. However, business processes are known to be complex and distributed among multiple business entities. As a result, the impact of new IT on an entire business process is typically unknown as quantitative methods for evaluation are missing. Therefore, in this paper, we propose a process-oriented methodology for evaluating the impact of IT on a business process. In our method, process mining and discrete event simulation are key ingredients. Based on automatically stored data, process mining allows for obtaining detailed knowledge on a business process, e.g., it can be discovered how a business process is actually executed. Using discrete event simulation, a model can be build which accurately mimics the discovered process and which can subsequently be used for exploring and evaluating various redesign of the same process.