Systems level modeling of a neuronal network subserving intrinsic alertness

Mottaghy, Felix M.; Hinckeldey, Klaus Willmes-von; Horwitz, Barry; Müller, Hans-W.; Krause, Bernd J.; Sturm, Walter

doi:10.1016/j.neuroimage.2005.07.034

Cited by 77 publications

(65 citation statements)

References 55 publications

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“…In the present experiment, such an up-regulation of arousal seems to be Mottaghy , 2006et al Sturm , 1999et al Sturm , 2004 behaviourally reflected by the nonsignificant tendency shown by verbalizer participants to respond faster than non-verbalizers, which was paralleled by an activation of the brain stem as a part of the arousal/alerting system. The role of the ACC in the control of arousal was further underlined by a review of PET studies focusing on this structure ( ).…”

Section: Verbalizers > Non-verbalizers 80 Valid Conditionmentioning

confidence: 43%

Neural correlates of primary and reflective consciousness of spatial orienting

et al. 2008

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Section: Verbalizers > Non-verbalizers 80 Valid Conditionmentioning

confidence: 43%

Neural correlates of primary and reflective consciousness of spatial orienting

et al. 2008

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“…Whenever new information is presented, activity levels of the dACC reflect the salience of the new information for predicting future outcomes (Critchley, 2005;Behrens et al, 2007), guiding optimal decision making in an uncertain world (Kennerley et al, 2006). The dorsal ACC is anatomically (Ghashghaei et al, 2007) and functionally heavily connected to the subgenual ACC (Margulies et al, 2007;Stein et al, 2007) as well as to the thalamus and brainstem (Mottaghy et al, 2006). The subgenual ACC (BA25) is functionally also connected to the parahippocampal gyrus (Kahn et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Group independent component analysis of resting state EEG in large normative samples

Congedo

John

Ridder³

et al. 2010

International Journal of Psychophysiology

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EEG (Electroencephalography) resting state was studied by means of group blind source separation (gBSS), employing a test-retest strategy in two large-sample normative databases (N=57 and N=84). Using a BSS method in the complex Fourier domain and a model-driven distributed inverse solution we closely replicate both the spatial distribution and spectral pattern of seven source components. Norms were then constructed for their spectral power so as to allow testing patients against the norms. As compared to existing normative databases based on scalp spectral measures, the resulting tool defines a smaller number of features with very little inter-correlation. Furthermore, these features are physiologically meaningful as they relate the activity of several brain regions, forming a total of seven patterns, each with a peculiar spatial distribution and spectral profile. This new tool, that we name normative independent component analysis (NICA), may serve as an adjunct to diagnosis and assessment of abnormal brain functioning and aid in research on normal resting state networks.

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“…This notion is corroborated by a PET study [Paus et al, 1997], in which the decline of arousal during a 60-min vigilance task covaried with activity in ACC and midbrain structures. Further support comes from an effective-connectivity analysis of brain activity during a simple-RT task [Mottaghy et al, 2006], which revealed top-down influences of the ACC on thalamus and brainstem structures associated with arousal regulation. Notably, in a sensorimotor control condition similar to the one we used here, this top-down connectivity was absent.…”

Section: Arousal Regulation and The Implementation Of Task Setsmentioning

confidence: 99%

“…Apart from modulating activity in other cortical regions via direct cortico-cortical interactions (e.g., connections between ACC and mid-cingulate motor zones), ACC and insula might indirectly send modulatory signals to cortical areas via subcortical loops that involve brainstem arousal centers [Corbetta et al, 2008]. The LC, a major brainstem nucleus involved in arousal regulation [Jones, 2003], receives input from ACC and insula [Aston- Jones and Cohen, 2005;Ongü r et al, 2003], which might top-down modulate LC firing activity [Mottaghy et al, 2006]. This top-down control may drive changes in tonic LC firing, thereby producing transitions between behavioral states characterized by different arousal levels (e.g., sleep or alert wakefulness; Aston- Jones and Cohen, 2005).…”

Section: Arousal Regulation and The Implementation Of Task Setsmentioning

confidence: 99%

Staying responsive to the world: Modality‐specific and ‐nonspecific contributions to speeded auditory, tactile, and visual stimulus detection

Langner

Kellermann

Eickhoff

et al. 2011

Human Brain Mapping

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Sustained responsiveness to external stimulation is fundamental to many time-critical interactions with the outside world. We used functional magnetic resonance imaging during speeded stimulus detection to identify convergent and divergent neural correlates of maintaining the readiness to respond to auditory, tactile, and visual stimuli. In addition, using a multimodal condition, we investigated the effect of making stimulus modality unpredictable. Relative to sensorimotor control tasks, all three unimodal detection tasks elicited stronger activity in the right temporo-parietal junction, inferior frontal cortex, anterior insula, dorsal premotor cortex, and anterior cingulate cortex as well as bilateral mid-cingulum, midbrain, brainstem, and medial cerebellum. The multimodal detection condition additionally activated left dorsal premotor cortex and bilateral precuneus. Modality-specific modulations were confined to respective sensory areas: we found activity increases in relevant, and decreases in irrelevant sensory cortices. Our findings corroborate the modality independence of a predominantly right-lateralized core network for maintaining an alert (i.e., highly responsive) state and extend previous results to the somatosensory modality. Monitoring multiple sensory channels appears to induce additional processing, possibly related to stimulus-driven shifts of intermodal attention. The results further suggest that directing attention to a given sensory modality selectively enhances and suppresses sensory processing-even in simple detection tasks, which do not require inter- or intra-modal selection.

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Systems level modeling of a neuronal network subserving intrinsic alertness

Cited by 77 publications

References 55 publications

Neural correlates of primary and reflective consciousness of spatial orienting

Neural correlates of primary and reflective consciousness of spatial orienting

Group independent component analysis of resting state EEG in large normative samples

Staying responsive to the world: Modality‐specific and ‐nonspecific contributions to speeded auditory, tactile, and visual stimulus detection

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