Systems Genomics in the Age of Next Generation Sequencing (Part I)

Suravajhala, Prashanth

doi:10.2174/138920292007200101105336

Cited by 1 publication

(2 citation statements)

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“…Systems genomics is an important part of current bioscience, providing evidence-based theoretical and empirical discoveries [ 1 , 2 ]. However, systems genomics approaches are rarely used in cytogenetic/cytogenomic research ( i.e ., genome analysis at chromosomal and subchromosomal levels) regardless of the proven efficiency and applicability [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Obviously, the described systems cytogenomics workflow may be expanded. In our opinion, the expansion of systems cytogenomics workflow would include sequencing data and the analysis by systems genomics methods [ 1 , 2 , 11 ]. In addition, one has is to be aware of current achievements in 3D genomics (spatial-dependent genome behavior in interphase nuclei) [ 39 , 40 ], which could also be included in a systems cytogenomics workflow.…”

Section: Introductionmentioning

confidence: 99%

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Systems Cytogenomics: Are We Ready Yet?

Iourov¹,

Vorsanova²,

Yurov³

2021

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: With the introduction of systems theory to genetics, numerous opportunities for genomic research have been identified. Consequences of DNA sequence variations are systematically evaluated using the network- or pathway-based analysis, a technological basis of systems biology or, more precisely, systems genomics. Despite comprehensive descriptions of advantages offered by systems genomic approaches, pathway-based analysis is uncommon in cytogenetic (cytogenomic) studies, i.e. genome analysis at the chromosomal level. Here, we would like to express our opinion that current cytogenomics benefits from the application of systems biology methodology. Accordingly, systems cytogenomics appears to be a biomedical area requiring more attention than it actually receives.

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Section: Introductionmentioning

confidence: 99%