Systems for localized release to mimic paracrine cell communication in vitro

Ansorge, Michael; Pompe, Tilo

doi:10.1016/j.jconrel.2018.03.028

Cited by 9 publications

(4 citation statements)

References 149 publications

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“…The controlled release of bioactive factors from micro-/nanoparticles in a localized and gradient-style manner can offer strategies to mimics the paracrine communication of cells (33). The delivery of bioactive factors alone (e.g., VEGF) has been proven to be an effective strategy to induce angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases

et al. 2020

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Development of new approaches to biomimetically reconstruct vasculature networks remains challenging in regenerative medicine. We introduce a particle-based artificial stem cell spheroid (ASSP) technology that recapitulates paracrine functions of three-dimensional (3D) SSPs for vasculature regeneration. Specifically, we used a facile method to induce the aggregation of stem cells into 3D spheroids, which benefited from hypoxia microenvironment–driven and enhanced secretion of proangiogenic bioactive factors. Furthermore, we artificially reconstructed 3D spheroids (i.e., ASSP) by integration of SSP-secreted factors into micro-/nanoparticles with cell membrane–derived surface coatings. The easily controllable sizes of the ASSP particles provided superior revascularization effects on the ischemic tissues in hindlimb ischemia models through local administration of ASSP microparticles and in myocardial infarction models via the systemic delivery of ASSP nanoparticles. The strategy offers a promising therapeutic option for ischemic tissue regeneration and addresses issues faced by the bottlenecked development in the delivery of stem cell therapies.

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Section: Discussionmentioning

confidence: 99%

Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases

et al. 2020

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“…Intercellular communications occur via direct cellular interactions in which cell surface proteins act as mediators able, or not, to bind to the ECM (juxtacrine signaling). Alternatively, cells release local mediators into the ECM to create self-control signals (autocrine signaling) and send information to neighboring cells (paracrine signaling) or reach target cells in long distances via hormones (endocrine signaling) (Ansorge and Pompe, 2018). The local mediators are peptides or growth factors which control many cellular activities.…”

Section: Ecm Structural Molecules and Soluble Factorsmentioning

confidence: 99%

Extracellular Matrix Composition and Remodeling: Current Perspectives on Secondary Palate Formation, Cleft Lip/Palate, and Palatal Reconstruction

Paiva

Maas

Santos

et al. 2019

Front. Cell Dev. Biol.

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Craniofacial development comprises a complex process in humans in which failures or disturbances frequently lead to congenital anomalies. Cleft lip with/without palate (CL/P) is a common congenital anomaly that occurs due to variations in craniofacial development genes, and may occur as part of a syndrome, or more commonly in isolated forms (non-syndromic). The etiology of CL/P is multifactorial with genes, environmental factors, and their potential interactions contributing to the condition. Rehabilitation of CL/P patients requires a multidisciplinary team to perform the multiple surgical, dental, and psychological interventions required throughout the patient's life. Despite progress, lip/palatal reconstruction is still a major treatment challenge. Genetic mutations and polymorphisms in several genes, including extracellular matrix (ECM) genes, soluble factors, and enzymes responsible for ECM remodeling (e.g., metalloproteinases), have been suggested to play a role in the etiology of CL/P; hence, these may be considered likely targets for the development of new preventive and/or therapeutic strategies. In this context, investigations are being conducted on new therapeutic approaches based on tissue bioengineering, associating stem cells with biomaterials, signaling molecules, and innovative technologies. In this review, we discuss the role of genes involved in ECM composition and remodeling during secondary palate formation and pathogenesis and genetic etiology of CL/P. We also discuss potential therapeutic approaches using bioactive molecules and principles of tissue bioengineering for state-of-the-art CL/P repair and palatal reconstruction.

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“…Due to the indispensable role of chemokines in immunity, understandably, the main focus of microfluidics for immune microenvironment engineering is currently toward generating gradients. Unfortunately, stable short‐range gradients similar to the in vivo situation (cell‐like point source) are hard to achieve with microfluidic systems . Possibly, microparticles as affinity‐based cytokine point sources offer an approach to mimic cytokine gradient and study cell–cell communication in vitro (Figure D).…”

Section: Reverse Engineering Of the Immune Microenvironmentmentioning

confidence: 99%

Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering

Witzel¹,

Nasser

Garcia-Sabaté

et al. 2018

Adv Healthcare Materials

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The immune microenvironment presents a diverse panel of cues that impacts immune cell migration, organization, differentiation, and the immune response. Uniquely, both the liquid and solid phases of every specific immune niche within the body play an important role in defining cellular functions in immunity at that particular location. The in vivo immune microenvironment consists of biomechanical and biochemical signals including their gradients, surface topography, dimensionality, modes of ligand presentation, and cell–cell interactions, and the ability to recreate these immune biointerfaces in vitro can provide valuable insights into the immune system. This manuscript reviews the critical roles played by different immune cells and surveys the current progress of model systems for reverse engineering of immune microenvironments with a focus on lymphoid tissues.

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Systems for localized release to mimic paracrine cell communication in vitro

Cited by 9 publications

References 149 publications

Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases

Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases

Extracellular Matrix Composition and Remodeling: Current Perspectives on Secondary Palate Formation, Cleft Lip/Palate, and Palatal Reconstruction

Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering

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