Systems Biology Perspectives for Studying Neurodevelopmental Events

Abstract

Brain development follows a complex process orchestrated by diverse molecular and cellular events for which a perturbation can cause pathologies. In fact, multiple neuronal cell fate decisions driven by complex gene regulatory programs are involved in neurogenesis and neurodevelopment, and their characterization are part of the current challenges on neurobiology. In this chapter, we provide an overview of the various genomic strategies in use to explore the spatiotemporally defined gene regulatory wires implicated in brain development. Finally, we will discuss the intake of these approaches for understanding the multifactorial events implicated in neurodevelopment and the future requirements for further expanding our understanding of the brain.