Systems Biology in Toxicology and Environmental Health

Yosim, Andrew; Fry, Rebecca C.

doi:10.1016/b978-0-12-801564-3.00001-8

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The transcriptomic data are then analyzed at the biological pathway level to interpret functional and biological outcomes of the differential gene expression; this can lead to the generation of novel hypotheses of cellular and molecular mechanisms of action of toxicants. 23 Only a few studies have used transcriptomic approaches to investigate the mechanisms of action of mustard agents in the lung. These include analyses of transcriptional responses of primary bronchial epithelial cells exposed to SM in vitro, lung tissue after intravenous administration of SM to rats, and lung tissue recovered from patients 25 years after exposure to SM.…”

Section: Discussionmentioning

confidence: 99%

“…In RNA‐seq, effects of a toxicant on expression of thousands of genes are simultaneously analyzed to provide a snapshot of the transcriptional response to exposure. The transcriptomic data are then analyzed at the biological pathway level to interpret functional and biological outcomes of the differential gene expression; this can lead to the generation of novel hypotheses of cellular and molecular mechanisms of action of toxicants 23 . Only a few studies have used transcriptomic approaches to investigate the mechanisms of action of mustard agents in the lung.…”

Section: Discussionmentioning

confidence: 99%

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Transcriptional profiling of lung macrophages during pulmonary injury induced by nitrogen mustard

Smith

Venosa

Gow

et al. 2020

Annals of the New York Academy of Sciences

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Nitrogen mustard (NM) and sulfur mustard are cytotoxic alkylating agents that cause severe and progressive damage to the respiratory tract. Evidence indicates that macrophages play a key role in the acute inflammatory phase and the later resolution/profibrotic phase of the pathogenic response. These diverse roles are mediated by inflammatory macrophages broadly classified as M1 proinflammatory and M2 anti-inflammatory that sequentially accumulate in the lung in response to injury. The goal of the present study was to identify signaling mechanisms contributing to macrophage activation in response to mustards. To accomplish this, we used RNA sequencing to analyze the gene expression profiles of lung macrophages isolated 1 and 28 days after intratracheal exposure of rats to NM (0.125 mg/kg) or phosphate-buffered saline control. We identified 641 and 792 differentially expressed genes 1 and 28 days post-NM exposure, respectively. These genes are primarily involved in processes related to cell movement and are regulated by cytokines, including tumor necrosis factor-α, interferon-γ, and interleukin-1β. Some of the most significantly enriched canonical pathways included STAT3 and NF-κB signaling. These cytokines and pathways may represent potential targets for therapeutic intervention to mitigate mustard-induced lung toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transcriptional profiling of lung macrophages during pulmonary injury induced by nitrogen mustard

Smith

Venosa

Gow

et al. 2020

Annals of the New York Academy of Sciences

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Enhanced Linear and Non Linear Optical Activity of Lead Onto L-Threonine Cadmium Acetate Crystal

Queen¹,

Bright

Delphine³

et al. 2021

Preprint

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Herein, we describe the growth and characterization of new crystal lead doped L-Threonine cadmium acetate (LTCA). The supramolecular coordination compounds are crystallized by slow evaporation technique at ambient temperature. The X-ray diffraction techniques confirm monoclinic crystal system and the presence of lead onto the LTCA lattice. L-Threonine amino acids have the unique properties like zwitter ionic nature and molecular chirality, which improves the optical properties of the crystal. The linear optical parameters such as optical band gap and refractive indexes are estimated from Uv-Vis analysis. The variation of dielectric constant, dielectric loss with frequency is studied using LCR meter. Due to the electropositive character of lead the static permittivity increases. Magnetic behavior changes to paramagnetic nature due to the inclusion of lead. TG/DTA analysis suggests, the crystal is thermally stable up to 135.32°C. Using Nd-YAG laser the NLO property was studied and the crystal shows higher SHG efficiency than the LTCA crystal.

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Systems Biology in Toxicology and Environmental Health

Cited by 2 publications

References 26 publications

Transcriptional profiling of lung macrophages during pulmonary injury induced by nitrogen mustard

Transcriptional profiling of lung macrophages during pulmonary injury induced by nitrogen mustard

Enhanced Linear and Non Linear Optical Activity of Lead Onto L-Threonine Cadmium Acetate Crystal

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