Systems biology approach: Panacea for unravelling host-virus interactions and dynamics of vaccine induced immune response

Wani, Sajad A.; Sahu, Anamika; Saxena, Shikha; Hussain, Shahid; Pandey, Awadh Bihari; Kanchan, Sonam; Sahoo, Aditya Prasad; Mishra, Bina; Tiwari, Ashok Kumar; Mishra, Bishnu Prasad; Gandham, Ravi Kumar; Singh, Raj Kumar

doi:10.1016/j.genrep.2016.08.002

Cited by 3 publications

(2 citation statements)

References 54 publications

(93 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comprehensive understanding of host-virus interactions requires insight into the communication between layers of biological systems at the protein, messenger RNA, genetic, lipid, and metabolite levels (109). While QTV can offer detailed information about changes in protein abundance over time and can indicate potential viral mechanisms, a greater level of resolution can now be achieved via integration of multi-omics data, identifying relationships between transcripts, proteins, lipids, and metabolites through correlations in abundance (110).…”

Section: Integrative Omics Approaches For Time-resolved Analysis Of Viral Infectionmentioning

confidence: 99%

Quantitative Temporal Viromics

Fletcher-Etherington

Weekes

2021

Annu. Rev. Virol.

View full text Add to dashboard Cite

The abundance, localization, modifications, and protein-protein interactions of many host cell and virus proteins can change dynamically throughout the course of any viral infection. Studying these changes is critical for a comprehensive understanding of how viruses replicate and cause disease, as well as for the development of antiviral therapeutics and vaccines. Previously, we developed a mass spectrometry–based technique called quantitative temporal viromics (QTV), which employs isobaric tandem mass tags (TMTs) to allow precise comparative quantification of host and virus proteomes through a whole time course of infection. In this review, we discuss the utility and applications of QTV, exemplified by numerous studies that have since used proteomics with a variety of quantitative techniques to study virus infection through time. Expected final online publication date for the Annual Review of Virology, Volume 8 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

show abstract

Section: Integrative Omics Approaches For Time-resolved Analysis Of Viral Infectionmentioning

confidence: 99%

Quantitative Temporal Viromics

Fletcher-Etherington

Weekes

2021

Annu. Rev. Virol.

View full text Add to dashboard Cite

show abstract

“…Key features of complex systems are unexpected dynamic and unexpected outcomes of interventions, called ‘emergent behavior’, bifurcation (or tipping) points where a division into branches or sub-groups occurs, i.e., fractal behavior, and unrealized multiple equilibria or steady states [ 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. The population dynamics of pathogens and pathogen-host interactions depend on multiple factors, including natural and anthropogenic factors, along with other hidden factors, and are often underestimated.…”

Section: Introductionmentioning

confidence: 99%

System Complexity in Influenza Infection and Vaccination: Effects upon Excess Winter Mortality

Jones¹,

Ponomarenko

2022

Infectious Disease Reports

View full text Add to dashboard Cite

Unexpected outcomes are usually associated with interventions in complex systems. Excess winter mortality (EWM) is a measure of the net effect of all competing forces operating each winter, including influenza(s) and non-influenza pathogens. In this study over 2400 data points from 97 countries are used to look at the net effect of influenza vaccination rates in the elderly aged 65+ against excess winter mortality (EWM) each year from the winter of 1980/81 through to 2019/20. The observed international net effect of influenza vaccination ranges from a 7.8% reduction in EWM estimated at 100% elderly vaccination for the winter of 1989/90 down to a 9.3% increase in EWM for the winter of 2018/19. The average was only a 0.3% reduction in EWM for a 100% vaccinated elderly population. Such outcomes do not contradict the known protective effect of influenza vaccination against influenza mortality per se—they merely indicate that multiple complex interactions lie behind the observed net effect against all-causes (including all pathogen causes) of winter mortality. This range from net benefit to net disbenefit is proposed to arise from system complexity which includes environmental conditions (weather, solar cycles), the antigenic distance between constantly emerging circulating influenza clades and the influenza vaccine makeup, vaccination timing, pathogen interference, and human immune diversity (including individual history of host-virus, host-antigen interactions and immunosenescence) all interacting to give the observed outcomes each year. We propose that a narrow focus on influenza vaccine effectiveness misses the far wider complexity of winter mortality. Influenza vaccines may need to be formulated in different ways, and perhaps administered over a shorter timeframe to avoid the unanticipated adverse net outcomes seen in around 40% of years.

show abstract

Conference Report: LPMHealthcare Emerging Viruses 2023 (EVOX23): Pandemics—Learning from the Past and Present to Prepare for the Future

Jenkins,

Mapulanga,

Thapa

et al. 2024

Pathogens

View full text Add to dashboard Cite

The emergence of SARS-CoV-2 has meant that pandemic preparedness has become a major focus of the global scientific community. Gathered in the historic St Edmund Hall college in Oxford, the one-day LPMHealthcare conference on emerging viruses (6 September 2023) sought to review and learn from past pandemics—the current SARS-CoV-2 pandemic and the Mpox outbreak—and then look towards potential future pandemics. This includes an emphasis on monitoring the “traditional” reservoirs of viruses with zoonotic potential, as well as possible new sources of spillover events, e.g., bats, which we are coming into closer contact with due to climate change and the impacts of human activities on habitats. Continued vigilance and investment into creative scientific solutions is required for issues including the long-term physical and psychological effects of COVID-19, i.e., long COVID. The evaluation of current systems, including environmental monitoring, communication (with the public, regulatory authorities, and governments), and training; assessment of the effectiveness of the technologies/assays we have in place currently; and lobbying of the government and the public to work with scientists are all required in order to build trust moving forward. Overall, the SARS-CoV-2 pandemic has shown how many sectors can work together to achieve a global impact in times of crisis.

show abstract

Systems biology approach: Panacea for unravelling host-virus interactions and dynamics of vaccine induced immune response

Cited by 3 publications

References 54 publications

Quantitative Temporal Viromics

Quantitative Temporal Viromics

System Complexity in Influenza Infection and Vaccination: Effects upon Excess Winter Mortality

Conference Report: LPMHealthcare Emerging Viruses 2023 (EVOX23): Pandemics—Learning from the Past and Present to Prepare for the Future

Contact Info

Product

Resources

About