Systems Biology Analysis of Cell Death Pathways in Cancer: How Collaborative and Interdisciplinary Research Helps

Zhivotovsky, Boris

doi:10.1007/978-94-007-1567-7_10

Cited by 2 publications

(2 citation statements)

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“…Programmed cell death (PCD), systematically classified into apoptosis, autophagy and programmed necrosis, is proposed to be cell dying in a pathological state to keep host in equilibrium via specific cellular mechanism and various signaling pathways ( Tan et al, 2009 ). Apoptosis, autophagy and programmed necrosis can be distinguished by their special morphological differences and physiological process ( Zhivotovsky, 2011 ). All of them have certain association with each other and they may share the same signaling pathways or downstream effected adaptors to induce cancer cells death.…”

Section: Tlrs and Programmed Cell Deathmentioning

confidence: 99%

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

2018

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Toll-like receptors (TLRs) activation enables host to recognize a large number of pathogen-associated molecule patterns (PAMPs), ignite immune cells to discriminate between self and non-self, and then promote the following innate and adaptive immune responses. Accumulated clinical/preclinical evidences have proven TLRs to be critical role in the autoimmune diseases, including inflammatory and tumor-associated diseases. Activation of TLRs is becoming or has been a target for cancer treatment. It is shown that TLRs can induce preferable anti-tumor effect by eliciting inflammatory cytokines expression and cytotoxic T lymphocytes (CTLs) response. As adjuvant, TLRs agonists can launch a strong immune response to assist cancer radiotherapy and bio-chemotherapy. On the other hand, tumor-associated antigens acting as PAMPs, can also activate TLRs and induce tumor gene-related programmed cell death, including apoptosis, autophagy and programmed necrosis. While there are also arguments that the excessive TLRs expression will promote tumor deterioration in various organisms, as the TLR-induced inflammation will accelerate the cancer cells boost in the tumor microenvironment (TME). However, the effect of TLRs acting on cancers is still not quite clear today. In this review, we will summarize the recent researches of TLRs in cancer treatment and their role in TME, giving a brief overview on future expectation.

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Section: Tlrs and Programmed Cell Deathmentioning

confidence: 99%

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

2018

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“…Especially, we address a number of recent studies that provided new insights into apoptosis regulation since previous reviews have been written [11-14]. These studies include the determination of the DISC stoichiometry [15,16], molecular determinants of type I/type II apoptotic signaling [17], novel statistical methods of parameter estimation and model discrimination of cell death models [18], and using mathematical modeling of apoptosis for the development of novel anticancer therapies [19-21].…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of apoptosis

Schleich

Lavrik

2013

Cell Commun Signal

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Apoptosis is a form of programmed cell death, which is fundamental to all multicellular organisms. Deregulation of apoptosis leads to a number of severe diseases including cancer. Apoptosis is initiated either by extrinsic signals via stimulation of receptors at the cellular surface or intrinsic signals, such as DNA damage or growth factor withdrawal. Apoptosis has been extensively studied using systems biology which substantially contributed to the understanding of this death signaling network. This review gives an overview of mathematical models of apoptosis and the potential of systems biology to contribute to the development of novel therapies for cancer or other apoptosis-related diseases.

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Systems Biology Analysis of Cell Death Pathways in Cancer: How Collaborative and Interdisciplinary Research Helps

Cited by 2 publications

References 77 publications

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

Mathematical modeling of apoptosis

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