Systems biological approaches towards understanding cellulase production by Trichoderma reesei

Kubicek, Christian P.

doi:10.1016/j.jbiotec.2012.05.020

Cited by 134 publications

(92 citation statements)

References 42 publications

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“…Endoglucanases from various sources belong to different glycoside hydrolase families, among which the major are 5-9, 12, 44, 45, 48, 51 and 74. Most of the fungal endoglucanases contain a catalytic module with carbohydrate-binding module (CBM), but catalytic module without CBM was also reported from fungal species (89). Multiple catalytic modules and CBMs are present in bacterial endoglucanases.…”

Section: Lipoxygenasesmentioning

confidence: 99%

Applications of Microbial Enzymes in Food Industry

Sindhu

Binod

Ummalyma

et al. 2018

Food Technol. Biotechnol.

526

230

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SUMMARYThe use of enzymes or microorganisms in food preparations is an age-old process. With the advancement of technology, novel enzymes with wide range of applications and specificity have been developed and new application areas are still being explored. Microorganisms such as bacteria, yeast and fungi and their enzymes are widely used in several food preparations for improving the taste and texture and they offer huge economic benefits to industries. Microbial enzymes are the preferred source to plants or animals due to several advantages such as easy, cost-effective and consistent production. The present review discusses the recent advancement in enzyme technology for food industries. A comprehensive list of enzymes used in food processing, the microbial source of these enzymes and the wide range of their application are discussed.

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Section: Lipoxygenasesmentioning

confidence: 99%

Applications of Microbial Enzymes in Food Industry

Sindhu

Binod

Ummalyma

et al. 2018

Food Technol. Biotechnol.

526

230

View full text Add to dashboard Cite

show abstract

“…In addition to cellulases, some other recently-described enzymes, such as the copper-requiring polysaccharide monooxygenases which have synergy with the exo-and endoglucanases, and elastin-like proteins which enhance access of the cellulases to the cellulose chains ends, are involved in lignocellulose hydrolysis (Leggio et al, 2012;Kubicek, 2013;Kricka et al, 2014;Nakatani et al, 2013). Cellulase enzymes are naturally produced by a variety of fungi such as Trichoderma, Aspergillus, Talaromyces, and several anaerobic bacteria such as species of the Clostridium and Ruminococcus genera, which can be used as sources of cellulase genes for enhancing cellulase activity in yeasts (Martinez et al, 2008;Fontes and Gilbert, 2010;Kubicek, 2013;Kricka et al, 2014). To achieve an efficient and complete hydrolysis of lignocelluloses, at least one copy of each of the cellulase genes must be functionally expressed in the ethanologenic host organism (e.g.…”

Section: Engineering An Ethanologen To Be Cellulolyticmentioning

confidence: 99%

Advances in consolidated bioprocessing systems for bioethanol and butanol production from biomass: a comprehensive review

2015

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HIGHLIGHTS Various CBP strategies have been discussed. Recently, lignocellulosic biomass as the most abundant renewable resource has been widely considered for bioalcohols production. However, the complex structure of lignocelluloses requires a multi-step process which is costly and time consuming. Although, several bioprocessing approaches have been developed for pretreatment, saccharification and fermentation, bioalcohols production from lignocelluloses is still limited because of the economic infeasibility of these technologies. This cost constraint could be overcome by designing and constructing robust cellulolytic and bioalcohols producing microbes and by using them in a consolidated bioprocessing (CBP) system. This paper comprehensively reviews potentials, recent advances and challenges faced in CBP systems for efficient bioalcohols (ethanol and butanol) production from lignocellulosic and starchy biomass. The CBP strategies include using native single strains with cellulytic and alcohol production activities, microbial co-cultures containing both cellulytic and ethanologenic microorganisms, and genetic engineering of cellulytic microorganisms to be alcohol-producing or alcohol producing microorganisms to be cellulytic. Moreover, high-throughput techniques, such as metagenomics, metatranscriptomics, next generation sequencing and synthetic biology developed to explore novel microorganisms and powerful enzymes with high activity, thermostability and pH stability are also discussed. Currently, the CBP technology is in its infant stage, and ideal microorganisms and/or conditions at industrial scale are yet to be introduced. So, it is essential to bring into attention all barriers faced and take advantage of all the experiences gained to achieve a high-yield and low-cost CBP process.

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“…Similar to the trend found for plant-cell-walldegrading enzymes, the number of CBMencoding proteins is reduced in T. reesei. It seems that T. reesei has lost several enzymes that degrade plant cell walls during its evolution to a saprotrophic organism because T. virens and T. atroviride, which evolved earlier than T. reesei (Kubicek 2013;Kubicek et al 2011), have a considerably higher number of GHs (260 and 257, respectively), and their number of these enzymes is higher.…”

Section: Enzyme Production a The Genomic Inventory For Substrate mentioning

confidence: 99%

10 Genomics Analysis of Biocontrol Species and Industrial Enzyme Producers from the Genus Trichoderma

et al. 2014

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Systems biological approaches towards understanding cellulase production by Trichoderma reesei

Abstract: Highlights► First systems biology review on Trichoderma reesei. ► First ‘omics comparison of Trichoderma reesei and other Trichoderma spp. ► The ‘omics results offer novel understanding of biomass hydrolyzing enzymes. ► Routes for further research are illustrated.

Cited by 134 publications

References 42 publications

Applications of Microbial Enzymes in Food Industry

Applications of Microbial Enzymes in Food Industry

Advances in consolidated bioprocessing systems for bioethanol and butanol production from biomass: a comprehensive review

10 Genomics Analysis of Biocontrol Species and Industrial Enzyme Producers from the Genus Trichoderma

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