Systems Approach to Vaginak Delivery of Drugs III: Simulation Studies Interfacing Steroid Release from Silicone Matrix and Vaginal Absorption in Rabbits

Ho, Norman F.H.; Suhardja, L.; Hwang, Shyh‐Lung; Owada, Eiji; Molokhia, Abdulla M.; Flynn, Gordon L.; Higuchi, W.I.; Park, J.Y.

doi:10.1002/jps.2600651106

Cited by 15 publications

(2 citation statements)

References 1 publication

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“…In addition to pH, other physiological factors may impact the absorption and efficacy of vaginally delivered drugs. Cyclical changes, associates to age, phase of the menstrual cycle, and pregnancy are known to modify the epithelial thickness and composition of vaginal fluids (41)(42)(43)(44)(45)(46)(47). Certainly, barriers to successful drug delivery and targeting such as a changing epithelial barrier, presence of biological fluids at the surface of the tissue, enzymatic activity of vaginal fluid, and hydrogen peroxide as well as other constituents produced by normal microflora have the potential to reduce biological activity of microbicide candidates if not considered during product development (48).…”

Section: Physiology Of the Vagina And Barriers To Drug Deliverymentioning

confidence: 99%

Vaginal Drug Delivery Systems for HIV Prevention

Rohan

Sassi

2009

AAPS J

140

130

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Abstract. Microbicides have become a principal focus for HIV prevention strategies. The successful design of drug delivery systems for vaginal microbicide drug candidates brings with it a multitude of challenges. It is imperative that the chemical and physical characteristics of the drug candidate and its mechanism of action be clearly understood and considered to successfully deliver and target drug candidates efficiently. In addition, an understanding of the dynamic nature of the vaginal environment, the tissue and innate barriers present, as well as patient preferences are critical considerations in the design of effective microbicide products. Although the majority of drug candidates clinically evaluated to date have been delivered using conventional semisolid aqueous-based gel dosage forms, drug delivery system design has recently been extended to include advanced delivery systems such as vaginal rings, quick-dissolve films, and tablets. Ultimately, it may be necessary to develop multiple dosage platforms for a single active agent to provide users with options that can be used within the constraints of their social environment, personal choice, and environmental conditions.

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Section: Physiology Of the Vagina And Barriers To Drug Deliverymentioning

confidence: 99%

Vaginal Drug Delivery Systems for HIV Prevention

Rohan

Sassi

2009

AAPS J

140

130

View full text Add to dashboard Cite

show abstract

“…Permeability studies on vaginal tissue obtained from animal models, such as rodent, rabbit, monkey, and sheep have been conducted. However, few studies comparing species have been performed 4–7. Permeability studies using cultured human vaginal‐cervical epithelial cells have been described in the literature,8–10 but there is a lack of information available on the permeability of human vaginal and cervical tissue.…”

Section: Introductionmentioning

confidence: 99%