Systemic zygomycosis

Benbow, Emyr W.; Stoddart, R. W.

doi:10.1136/pgmj.62.733.985

Cited by 29 publications

(15 citation statements)

References 159 publications

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“…Our experience confirms the devastating outcome of renal zygomycosis as described earlier [1,3,5] . Zygomycetes are opportunistic organisms with ubiquitous distribution in soil, decaying organic matter and air [4,5] .…”

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

“…Zygomycetes are opportunistic organisms with ubiquitous distribution in soil, decaying organic matter and air [4,5] . They have minimal intrinsic pathogenicity but are known to initiate an aggressive and often fatal infection in certain conditions such as diabetic ketoacidosis, lymphoproliferative disorders, renal failure and viral hepatitis [3][4][5] . The list of predisposing conditions continues to grow, the latest additions being desferrioxamine therapy for iron/ aluminum overload in dialysis patients [6] and intravenous drug abuse particularly in those with HIV infection [15][16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

“…whereas earlier term mucormycosis is no longer in the newer taxonomic classification [5] . The most common pathogenic species are Absidia corymbifera, Rhizopus oryza and Rhizomucor pusillus [3][4][5][6] .…”

mentioning

confidence: 99%

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Isolated Renal Zygomycosis: Novel Diagnostic and Prognostic Criteria with Experience of a Tertiary Care Center

Chipde¹,

Ranjan²,

Lal³

et al. 2012

Urol Int

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Background: Isolated renal zygomycosis is a life-threatening infection and difficult to diagnose ante mortem due to varied presentations. Most reports in the literature are case reports. We are presenting our experience of 10 patients. Materials and Methods: Retrospective data of 10 consecutive patients with primary renal zygomycosis, including 2 post-transplant patients, in our tertiary care center was analyzed. Epidemiological characteristics, predisposing conditions, clinical presentation, diagnostic findings and treatment outcomes were recorded. Characteristic radiological findings were recorded. Localized disease was managed by supportive treatment or percutaneous drainage and extensive disease with unilateral or bilateral nephrectomy. Renal involvement was confirmed in all patients by histopathology. Results: The mean age of presentation was 35 years. Five patients who had bilateral renal involvement presented with oliguric acute renal failure, hematuria and abdominal pain. Three had unilateral renal disease and presented with flank pain and fever. The two post-transplant patients presented with fever and graft dysfunction. Even after aggressive treatment 5 patients died, accounting for a mortality rate of 50%. Conclusion: Isolated renal zygomycosis can be diagnosed with typical radiological findings, combined with clinical, laboratory and histopathological features. This study describes the newer ante mortem radiological diagnostic criteria and prognostic predictors of the disease.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Isolated Renal Zygomycosis: Novel Diagnostic and Prognostic Criteria with Experience of a Tertiary Care Center

Chipde¹,

Ranjan²,

Lal³

et al. 2012

Urol Int

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“…13 Rampant and severe disease can occur in susceptible patients, including those who are status post organ transplantation or have diabetic ketoacidosis, leukemia or some form of immunosuppression. 1 Isolated or primary pulmonary mucormycosis with localized lung involvement and without evidence of dissemination is quite uncommon and is usually diagnosed at autopsy. 13 A number of factors contribute to the development of this fungal infection.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Mucormycosis Diagnosed by Fine Needle Aspiration Cytology

Bakshi¹,

Volk²

2001

Acta Cytologica

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Invasive pulmonary mucormycosis with rupture of the thoracic aorta

Kitabayashi

Hirokawa

Yamaguchi³

et al. 1998

Am. J. Hematol.

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We report an acute myelogenous leukemia patient with mucormycosis who died of massive hemoptysis during antifungal therapy. The diagnosis was made postmortem and autopsy revealed that the pulmonary nodule consisting of mucorales protruded over the luminal surface of the aorta. Microscopic examination showed the invasion of mucor hyphae into the wall of the aortic arch. Surgical treatment may be indicated for patients with pulmonary mucormycosis refractory to amphotericin B therapy.

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Systemic zygomycosis

Cited by 29 publications

References 159 publications

Isolated Renal Zygomycosis: Novel Diagnostic and Prognostic Criteria with Experience of a Tertiary Care Center

Isolated Renal Zygomycosis: Novel Diagnostic and Prognostic Criteria with Experience of a Tertiary Care Center

Pulmonary Mucormycosis Diagnosed by Fine Needle Aspiration Cytology

Invasive pulmonary mucormycosis with rupture of the thoracic aorta

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