Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine

Tousi, Babak; Papish, Steven W.

doi:10.1046/j.1365-2257.2002.00453.x

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…Treatment of the underlying HCL with either alpha-interferon or purine analogues may generally result in rapid improvement of the cutaneous scenario, up to complete regression of the vasculitic syndrome (7, 14, 15). A case of pharmacologically induced cutaneous manifestations in an HCL patient has also been described, as a consequence of the treatment of the disease itself (namely with cladribine) (16).…”

Section: Discussionmentioning

confidence: 99%

Leukocytoclastic Vasculitis Associated with Hairy Cell Leukemia at Diagnosis: A Case Report and Review of the Literature

Broccoli

Gandolfi

Pellegrini

et al. 2016

Tumori

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The clinical picture we have observed is of interest for the following reasons: i) it confirms an existing pathogenetic relationship between this lymphoproliferative disorder and its cutaneous manifestations, as suggested by the prompt resolution of the purpuric lesions upon cladribine administration; ii) it indicates that cladribine is an effective treatment for HCL-related paraneoplastic syndromes, including leukocytoclastic vasculitis; iii) the evolution and the outcomes of the paraneoplastic manifestations may be independent of those of the underlying leukemia, which showed less than a partial response to its initial treatment.

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Section: Discussionmentioning

confidence: 99%

Leukocytoclastic Vasculitis Associated with Hairy Cell Leukemia at Diagnosis: A Case Report and Review of the Literature

Broccoli

Gandolfi

Pellegrini

et al. 2016

Tumori

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“…Production of cytokines including tumour necrosis factor-α, transforming growth factor-β and various paracrine growth factors by leukaemic cells possibly contributes to the latter. While some studies have related the production of autoantibodies by the polyclonal bystander B cells to autoimmune disease, others have implicated treatment with anticancer drugs (eg, purine analogues) that could lead to a loss of auto regulatory T cells 5 18. The role of neutropenia, impaired function of monocytes and macrophages and infiltration of the reticuloendothelial system by leukaemic hairy cells are other proposed mechanisms 2.…”

Section: Discussionmentioning

confidence: 99%

Vasculitides associated with haematological malignancies: a case-based review

2012

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Autoimmune phenomena including vasculitis are known to be associated with malignancy, especially those that are haematological in origin. Vasculitis syndromes associated with malignant disease include cutaneous leucocytoclastic vasculitis, polyarteritis nodosa, Churg-Strauss syndrome, microscopic polyangiitis, Wegener's granulomatosis and Henoch-Schönlein purpura. We describe a patient whose initial presentation with vasculitis led to the diagnosis of hairy cell leukaemia.

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“…In particular, treatment with cladribine improves the cutaneous symptoms and complete regression of vasculitis was usually achieved [61,67,69,70,74]. On the other hand, cladribine itself can induce vasculitis in HCL patients [75,76].…”

Section: Vasculitis Syndromesmentioning

confidence: 99%

Skin changes in hairy cell leukemia

2020

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Skin lesions have been reported in about 10–12% of hairy cell leukemia (HCL) patients. Most are etiologically related to autoimmune or infectious processes, although secondary cutaneous neoplasms and drug-induced lesions are also reported. However, leukemia cutis with the direct infiltration of the skin by leukemic cells is extremely rare in HCL patients. This paper reviews the epidemiology, pathogenesis, clinical symptoms, diagnosis, and approach to treating skin lesions in HCL. A literature review of the MEDLINE database for articles in English concerning hairy cell leukemia, skin lesions, leukemia cutis, adverse events, infectious, cutaneous, drug reactions, neutrophilic dermatoses, secondary neoplasms, and vasculitis was conducted via PubMed. Publications from January 1980 to September 2020 were scrutinized. Additional relevant publications were obtained by reviewing the references from the chosen articles.

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Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine

Cited by 8 publications

References 8 publications

Leukocytoclastic Vasculitis Associated with Hairy Cell Leukemia at Diagnosis: A Case Report and Review of the Literature

Leukocytoclastic Vasculitis Associated with Hairy Cell Leukemia at Diagnosis: A Case Report and Review of the Literature

Vasculitides associated with haematological malignancies: a case-based review

Skin changes in hairy cell leukemia

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