Systemic Treatments for Noninfectious Vitreous Inflammation

Abstract

Vitreous inflammation, or vitritis, may result from many causes, including both infectious and noninfectious, including rheumatologic and autoimmune processes. Vitritis is commonly vision threatening and has serious sequelae. Treatment is frequently challenging, but, today, there are multiple methods of systemic treatment for vitritis. These categories include corticosteroids, antimetabolites, alkylating agents, T-cell inhibitors/calcineurin inhibitors, and biologic agents. These treatment categories were reviewed last year, but, even over the course of just a year, many therapies have made progress, as we have learned more about their indications and efficacy. We discuss here discoveries made over the past year on both existing and new drugs, as well as reviewing mechanisms of action, clinical dosages, specific conditions that are treated, adverse effects, and usual course of treatment for each class of therapy.

Biochemical Characteristics of Distal Vessels Endothelium in Patiеnts with Syndroms of Lumbosacral Radiculopathies and others Neurological Syndromes Lumbar Osteochondrosis in Recrudescence Phase

“…Note -** differences are significant between the group of LSR patients and all the rest of groups, (p < 0,01). Table 1 shows that IL-1β content in the control group corresponds to reference values of the norm for healthy examined subjects, given in the test-system "Bender MedSystem" and agrees with the data of other authors who used either analogous ordinary reagent sets, or sets of other firms [25,26].…”