Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model

Kim, Jeong‐Min; Chu, Kon; Jung, Keun‐Hwa; Song, Eun Kyeung; Kim, Se-Jeong; Sinn, Dong-In; Kim, Jinhee; Park, Dong-Kyu; Kang, Kyung-Mook; Hong, Nan Hyung; Park, Hee-Kwon; Won, Chong‐Hyun; Kim, Kyu-Han; Kim, Manho; Lee, Sang Kun; Roh, Jae-Kyu

doi:10.1016/j.brainres.2007.09.005

Cited by 152 publications

(118 citation statements)

References 47 publications

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“…Adult stem cells exist in many tissues, including bone marrow, skin, adipose tissue, tendon, lung, heart, liver, placenta, and umbilical cord blood [1][2][3][4][5][6][7][8][9]. Due to their low immunogenicity and immunoregulatory function, mesenchymal stem cells (MSCs) play a key role in tissue regeneration and have been used in clinical trials in therapy for severe refractory diseases [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Periodontal Ligament Stem Cells Regulate B Lymphocyte Function via Programmed Cell Death Protein 1

Liu

Ding

et al. 2013

Stem Cells

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Periodontal ligament stem cells (PDLSCs) have provided novel cell sources for tooth and periodontal tissue regeneration. Allogeneic PDLSCs can reconstruct periodontal ligament tissue that has been damaged by periodontal diseases and regulate T-cell immunity. However, the effect of PDLSCs on B cells remains unknown. Here, we treated periodontitis in a miniature pig model using allogeneic PDLSCs and showed a reduction in humoral immunity in the animals. When cocultured with normal B cells, human PDLSCs (hPDLSCs) had similar effects as bone marrow mesenchymal stem cells in suppressing B cell proliferation, differentiation, and migration, while intriguingly, hPDLSCs increased B cell viability by secreting interleukin-6. Mechanistically, hPDLSCs suppressed B cell activation through cell-to-cell contact mostly mediated by programmed cell death protein 1 and programmed cell death 1 ligand 1. Our data revealed a previously unrecognized function of PDLSCs in regulating humoral immune responses, which may represent a novel therapeutic strategy for immune-related disorders.

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Section: Introductionmentioning

confidence: 99%

Periodontal Ligament Stem Cells Regulate B Lymphocyte Function via Programmed Cell Death Protein 1

Liu

Ding

et al. 2013

Stem Cells

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“…Mesenchymal stem cells generated from murine or human adipose tissues have been well documented [13][14][15][16][17][18][19][20][21][22] and have been named as adipose-derived stem cells [14,15,19,20], adipose-derived adult stem cells [21], adipose derived stromal cells [16], adipose derived mesenchymal stem cells [18], adipose tissuederived stem cells [13], and adipose tissue stromal cells [17]. Systemic transplantation of human adipose-derived stem cells to attenuate cerebral inflammation and to facilitate motion recovery of rats from cerebral degeneration induced by ICH has been attempted [23]. We found previously that transplantation of the Nurr1-positive neuronal stem cells derived from the wisdom tooth of a young adult facilitated a significant recovery from neurological dysfunction in rats with an MCAO induced stroke [24].…”

Section: Introductionmentioning

confidence: 99%

Human adipose-derived stem cells for the treatment of intracerebral hemorrhage in rats via femoral intravenous injection

Yang

Lee

Pang

et al. 2012

Cellular and Molecular Biology Letters

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Human adipose-derived stem cells (huADSC) were generated from fat tissue of a 65-year-old male donor. Flow cytometry and reverse transcription polymerase chain reaction (RT-PCR) analyses indicated that the huADSC express neural cell proteins (MAP2, GFAP, nestin and β-III tubulin), neurotrophic growth factors (BDNF and GDNF), and the chemotactic factor CXCR4 and its corresponding ligand CXCL12. In addition, huADSC expressed

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“…The tissue respond differently to specific wavelengths and dosages [38,39]. Some of the effects of LILI on ADSCs are summarised in Table 1 factors and stem cells to repair tissues and organs [40][41][42]. ADSCs are mesenchymal stem cells and have been isolated from adipose tissue through collagenase enzyme digestion and centrifugation [43].…”

Section: Low Intensity Laser Irradiationmentioning

confidence: 99%

The role of adipose derived stem cells, smooth muscle cells and low intensity laser irradiation (LILI) in tissue engineering and regenerative medicine

Mvula

Abrahamse

2013

Open Life Sciences

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Tissue engineering and regenerative medicine has become the treatment of choice for several degenerative diseases. It involves the repairing or replacing of diseased or damaged cells or tissues. Stem cells have a key role to play in this multidisciplinary science because of their capacity to differentiate into several lineages. Adipose derived stem cells (ADSCs) are adult mesenchymal stem cells that are easily harvested and have the capacity to differentiate into cartilage, bone, smooth muscle, fat, liver and nerve cells. ADSCs have been found to differentiate into smooth muscle cells which play major roles in diseases such as asthma, hypertension, cancer and arteriosclerosis. Low Intensity Laser Irradiation (LILI), which involves the application of monochromatic light, has been found to increase viability, proliferation and differentiation in several types of cells including ADSCs. This review discusses the role of ADSCs, smooth muscle cells and LILI in the science of tissue engineering and regenerative medicine.

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Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model

Cited by 152 publications

References 47 publications

Periodontal Ligament Stem Cells Regulate B Lymphocyte Function via Programmed Cell Death Protein 1

Periodontal Ligament Stem Cells Regulate B Lymphocyte Function via Programmed Cell Death Protein 1

Human adipose-derived stem cells for the treatment of intracerebral hemorrhage in rats via femoral intravenous injection

The role of adipose derived stem cells, smooth muscle cells and low intensity laser irradiation (LILI) in tissue engineering and regenerative medicine

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