Systemic toxicity

Truisi, Germaine L.; Maibach, Howard I.; Hewitt, Philip

doi:10.3109/9781841848570.006

Cited by 1 publication

(1 citation statement)

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“…The cumulative impact of the continuous/repetitive use of even a low level of mercury-containing creams can lead to nephritic syndrome [28]. A study confirmed that application of of SLC containing inorganic mercury resulted in accumulation and absorption of mercury in the body [29].…”

Section: Resultsmentioning

confidence: 84%

Quantitative Estimation of the Hydroquinone, Mercury and Total Plate Count in Skin-Lightening Creams

et al. 2021

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Generally white color of the skin is regarded as a feature of superiority and prettiness around the world. Both the males and females in Pakistan apply skin-lightening creams (SLC) but they do not know about the side-effects of their constituents. Skin-lightening products include SLC and related ointments. The SLC are made by mixing fates and water in standard procedure. Here, 20 SLC specimens were obtained and subjected to mercury, hydroquinone and the total plate count (TPC). The hydroquinone in SLC was determined using HPLC, mercury level was assessed by ICP OES and finally TPC were computing by utilizing nutrient media (Agar). The hydroquinone in SLC ranged from 0 to 7.14 ± 0.18% with a median value of 0.33%. In 25% of the studied samples, hydroquinone was not detected, 70% of the samples showed values within the limit and 5% of the samples (1 sample) had a hydroquinone concentration above the permissible limit defined by Pakistan (5%). The mercury ranged 0-7.7 ppm, with a median value of 2.5 ppm. Mercury was detected in 95% of the samples; thus, only 5% of the samples had no mercury. In turn, 20% had mercury within the limit value while 75% of the samples had concentration above the Pakistan standard limit (1 ppm). Moreover, TPC obtained in this study was less than the allowable value set according to European Union (EU). Hence, the SLC samples showed high concentration of toxic constituents which could cause deleterious skin diseases. Government must monitor such kind of cosmetic products regularly in order to reduce the danger.

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Section: Resultsmentioning

confidence: 84%