Systemic therapy as First-Line Treatment for Patients with Metastatic Colorectal Cancer: A Systematic Review and Network meta-analysis of Randomized Clinical Trials
Abstract:Purpose: To assess the relative efficacy and safety of first-line systemic therapies in patients with metastatic CRC (mCRC).Experimental Design: A comprehensive literature review was conducted including MEDLINE, Embase, and the Cochrane Central Registry of Controlled Trials for phase II or III Randomized Controlled Trials (RCTs) published up to and including July 15, 2019.We included RCTs in which at least 1 intervention was either a chemotherapeutic agents (such as, fluorouracil, irinotecan, or oxaliplatin) o… Show more
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