Systemic Therapy and Its Surgical Implications in Patients with Resectable Liver Colorectal Cancer Metastases. A Report from the Western Canadian Gastrointestinal Cancer Consensus Conference

Abstract

The Western Canadian Gastrointestinal Cancer Consensus Conference (WCGCCC) convened virtually on 4 November 2021. The WCGCCC is an interactive multi-disciplinary conference attended by health care professionals, including surgical, medical, and radiation oncologists; pathologists; radiologists; and allied health care professionals from across four Western Canadian provinces, British Columbia, Alberta, Saskatchewan, and Manitoba, who are involved in the care of patients with gastrointestinal cancer. They participated in presentation and discussion sessions for the purpose of developing recommendations on the role of systemic therapy and its optimal sequence in patients with resectable metastatic colorectal cancer.

A Case of Simultaneous Resection of Recurrent Colorectal Liver Metastases as part of Colorectal Cancer Treatment Journey

“…Surgical resection remains the treatment of choice for colorectal liver metastases. Since unnecessary prolonged chemotherapy treatment might lead to increased liver toxicity and higher surgical morbidity, resection of metastases should be performed as soon as the metastases are technically resectable [6][7][8].…”

“…In the case of CRLM, the role of adjuvant chemotherapy is more debatable. Existing evidence suggests that this approach only improves DFS but not OS [8]. The role of perioperative chemotherapy in patients with resectable CRLM was explored in one randomized study, the European Organization for Research and Treatment of Cancer (EORTC) 40983.…”