Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue

Schlecht, Lisa Marie; Peters, Brian M.; Krom, Bastiaan P.; Freiberg, Jeffrey A.; Hänsch, Gertrud Maria; Filler, Scott G.; Jabra‐Rizk, Mary Ann; Shirtliff, Mark E.

doi:10.1099/mic.0.083485-0

Cited by 220 publications

(261 citation statements)

References 98 publications

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“…Perhaps the best studied interaction is the attachment of the two microbes. One such phenomena is "microbial hitchhiking," where intricate studies by Schlecht and coworkers (2015) identified the ability of S. aureus upon binding with fungal hyphae to facilitate its own invasion of host tissues [55]. This mechanism, which was dependent on the fungal adhesin ALS3, resulted in recovery of the bacteria from kidney tissue, whereas no recovery was observed in single-species infection.…”

Section: Angular Cheilitis: Partners In Crime or Peer Pressure?mentioning

confidence: 99%

“…Perhaps the most welldocumented candidal adhesin with regard to interkingdom interactions is ALS3. Genetic manipulation of this adhesin has been shown to reduce bacterial binding to hyphal filaments of C. albicans, reducing the invasive capacity of this relationship [55]. The role of this phenotype has been shown in several bacterial pathogens including Staphylococcus aureus, Streptococcus gordonii, and Streptococcus agalactiae [56][57][58].…”

Section: Caries: Slimy Residentsmentioning

confidence: 99%

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Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Delaney

Kean

Short

et al. 2018

Curr Clin Micro Rpt

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Purpose of Review Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.

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Section: Angular Cheilitis: Partners In Crime or Peer Pressure?mentioning

confidence: 99%

Section: Caries: Slimy Residentsmentioning

confidence: 99%

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Delaney

Kean

Short

et al. 2018

Curr Clin Micro Rpt

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“…Further, our previous in vivo studies have indicated that the interaction of these species may carry important clinical implications (36,37). In fact, several studies have reported the coisolation of these diverse species from a multitude of diseases such as periodontitis, denture stomatitis, cystic fibrosis, keratitis, ventilator-associated pneumonia, urinary tract catheters and burn wound infections (38)(39)(40)(41)(42).…”

mentioning

confidence: 99%

Clinical Implications of Oral Candidiasis: Host Tissue Damage and Disseminated Bacterial Disease

et al. 2015

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fThe clinical significance of polymicrobial interactions, particularly those between commensal species with high pathogenic potential, remains largely understudied. Although the dimorphic fungal species Candida albicans and the bacterium Staphylococcus aureus are common cocolonizers of humans, they are considered leading opportunistic pathogens. Oral candidiasis specifically, characterized by hyphal invasion of oral mucosal tissue, is the most common opportunistic infection in HIV ؉ and immunocompromised individuals. In this study, building on our previous findings, a mouse model was developed to investigate whether the onset of oral candidiasis predisposes the host to secondary staphylococcal infection. The findings demonstrated that in mice with oral candidiasis, subsequent exposure to S. aureus resulted in systemic bacterial infection with high morbidity and mortality. Histopathology and scanning electron microscopy of tongue tissue from moribund animals revealed massive C. albicans hyphal invasion coupled with S. aureus deep tissue infiltration. The crucial role of hyphae in the process was demonstrated using a non-hypha-producing and a noninvasive hypha-producing mutant strains of C. albicans. Further, in contrast to previous findings, S. aureus dissemination was aided but not contingent upon the presence of the Als3p hypha-specific adhesion. Importantly, impeding development of mucosal C. albicans infection by administering antifungal fluconazole therapy protected the animals from systemic bacterial disease. The combined findings from this study demonstrate that oral candidiasis may constitute a risk factor for disseminated bacterial disease warranting awareness in terms of therapeutic management of immunocompromised individuals.

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“…However, the literature on the interactions between these pathogens is limited. 29 The TSC containing three new mononuclear ruthenium(II)-arene complexes were displayed compromising antibacterial activities against Gram-positive bacterial strains. The data conceded that the standard ATCC strains of Gram-positive bacteria were more susceptible than Gram-negative ones.…”

Section: Antimicrobial Activity Of Organometallic Ruthenium(ii)-arenementioning

confidence: 99%

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

Yavuz¹,

Yaman²,

Öztürk³

et al. 2017

Dicle Tıp Dergisi

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Objective: Thiosemicarbazone (TSC) containing three new mononuclear ruthenium(II)-arene complexes were synthesized so as to contribute to the development of ruthenium complexes with pharmacologically attracted properties.Conclusion: The TSC 1-3 containing ruthenium(II)-arene complexes were successfully synthesized and their molecular structures were also determined by the spectroscopic methods. All ruthenium(II)-arene complexes showed higher antibacterial activities against Gram-positive bacterial strains than the Gram-negative ones. Original Article/Özgün AraştırmaKeywords: Half-sandwich Ru(II)-arene complexes, benzaldehyde thiosemicarbazone, p-cymene, antimicrobial activity, clinical isolate.Results: The spectroscopic data indicated that TSC 1 was bounded to the metal as a tridentate ligand with its thione sulfur atom, phenolic oxygen atom and azomethine nitrogen atom in the complex I, while TSC 2 and TSC 3 were bounded to metal center as bidentate manner through their thione sulfur atom and imine nitrogen (C=N) atom in the complexes II and III, respectively. The obtained antimicrobial activity results showed that these complexes efficiently inhibit the growth of Gram-positive bacterial strains.

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Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue

Cited by 220 publications

References 98 publications

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Clinical Implications of Oral Candidiasis: Host Tissue Damage and Disseminated Bacterial Disease

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

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