Systemic Staphylococcus aureus infection in restraint stressed mice modulates impaired immune response resulting in improved behavioral activities

Mahanti, Sayantika; Majhi, Arnab; Kundu, Kiran; Basu, Anirban; Bishayi, Biswadev

doi:10.1016/j.jneuroim.2015.09.003

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…Th1 mediates cellular immunity, which is able to capture intracellular bacteria, viruses, and cancer, inducing the secretion of IFN- γ cytokines, a Th2 response to humoral immunity, and IL-4 secretion [ 19 ]. Studies have shown that serum IFN- γ content is higher in mice following S. aureus infection [ 7 ]. Activate LAB increase Th1 type IFN- γ cytokine secretion in spleen cells of mice infected with S .…”

Section: Discussionmentioning

confidence: 99%

“…The ratio of Th1 and Th2 cells is important for normal immune response [ 5 ]; meanwhile, in an adaptive immune response IFN- γ is a subset of CD4 + T helper 1 cells (Th1) that plays an important role in severe inflammation [ 6 ] by promoting inflammatory response. S. aureus infection can induce the release of a variety of inflammatory factors, such as IFN- γ [ 7 ]. S. aureus can also cause intestinal infection.…”

Section: Introductionmentioning

confidence: 99%

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Mixed Lactobacillus plantarum Strains Inhibit Staphylococcus aureus Induced Inflammation and Ameliorate Intestinal Microflora in Mice

Ren

Gong

Shu

et al. 2017

BioMed Research International

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Objective. Staphylococcus aureus is an important pathogen that causes intestinal infection. We examined the immunomodulatory function of single and mixed Lactobacillus plantarum strains, as well as their impacts on the structure of the microbiome in mice infected with Staphylococcus aureus. The experiment was divided into three groups: protection, treatment, and control. Serum IFNand IL-4 levels, as well as intestinal sIgA levels, were measured during and 1 week after infection with Staphylococcus aureus with and without Lactobacillus plantarum treatment. We used 16s rRNA tagged sequencing to analyze microbiome composition. IFN-/IL-4 ratio decreased significantly from infection to convalescence, especially in the mixed Lactobacillus plantarum group. In the mixed Lactobacillus plantarum group the secretion of sIgA in the intestine of mice (9.4-9.7 ug/mL) was significantly higher than in the single lactic acid bacteria group. The dominant phyla in mice are Firmicutes, Bacteroidetes, and Proteobacteria. Treatment with mixed lactic acid bacteria increased the anti-inflammatory factor and the secretion of sIgA in the intestine of mice infected with Staphylococcus aureus and inhibited inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mixed Lactobacillus plantarum Strains Inhibit Staphylococcus aureus Induced Inflammation and Ameliorate Intestinal Microflora in Mice

Ren

Gong

Shu

et al. 2017

BioMed Research International

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“…A growing stream of studies have suggested that S. aureus ‐induced peripheral inflammatory or neuroinflammation is involved in the pathogenesis of mental disorders (Balczon et al., 2019 ; Mahanti et al., 2015 ). S. aureus could engage TLR2 to recognize bacterial lipoproteins and induce inflammatory cytokine production in the central nervous system (CNS) to trigger and maintain the neuroinflammatory process (de Morais et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Microglia activation in the mPFC mediates anxiety‐like behaviors caused by Staphylococcus aureus strain USA300

et al. 2022

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Introduction:Staphylococcus aureus (S. aureus) is considered as one of the major causative agents of serious hospital-and community-acquired infections. Recent studies have reported that S. aureus infection induced neuroinflammation and was linked with some mental disorders. To evaluate the effects of S. aureus infection on abnormal behaviors, we conducted the present study.Methods: A S. aureus USA300-infected mouse model was established using bacterial suspension injection into tail vein. A series of behavioral tests were performed after USA300 infection. The expression of cytokines was detected in serum and mPFC.The number and some morphological parameters of microglia were also evaluated by immunofluorescence staining.Results: Anxiety-like behaviors, instead of locomotor activity impairment or depression-like behaviors, were observed in mice infected with S. aureus USA300 compared with control. S. aureus USA300 infection caused overexpression of IL-6, TNF-α, and IL-1β in serum, resulted in microglial over-activation and excessive release of proinflammatory cytokines in the mPFC. In addition, overexpression of TLR2 accompanied by increased GLS1 and p-STAT3 was observed in the mPFC of mice infected with S. aureus USA300. Conclusion:This study provides evidence that S. aureus USA300 infection can lead to neuroinflammation in the mPFC of mice, which may contribute to the development of anxiety.

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Ciprofloxacin and dexamethasone in combination attenuate S. aureus induced brain abscess via neuroendocrine-immune interaction of TLR-2 and glucocorticoid receptor leading to behavioral improvement

Dey

Bishayi

2021

International Immunopharmacology

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Systemic Staphylococcus aureus infection in restraint stressed mice modulates impaired immune response resulting in improved behavioral activities

Cited by 3 publications

References 51 publications

Mixed Lactobacillus plantarum Strains Inhibit Staphylococcus aureus Induced Inflammation and Ameliorate Intestinal Microflora in Mice

Mixed Lactobacillus plantarum Strains Inhibit Staphylococcus aureus Induced Inflammation and Ameliorate Intestinal Microflora in Mice

Microglia activation in the mPFC mediates anxiety‐like behaviors caused by Staphylococcus aureus strain USA300

Ciprofloxacin and dexamethasone in combination attenuate S. aureus induced brain abscess via neuroendocrine-immune interaction of TLR-2 and glucocorticoid receptor leading to behavioral improvement

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