Systemic Severity and Organ Dysfunction in Subarachnoid Hemorrhage: A Large Retrospective Multicenter Cohort Study

Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage

“…Possible mechanisms of extracranial complications include catecholamine hyperactivity, hemodynamic dysfunction, and systemic inflammation. Kurtz et al found that the severity of non-neurological systemic organ dysfunction, as measured by nSOFA score, was related to aSAH hospitalization mortality [ 74 ]. Neurogenic pulmonary edema is associated with poor clinical outcome and believed to be closely associated with systemic inflammatory response [ 72 ].…”

“…Furthermore, SIRS criteria (i.e., increased white blood cell count and body temperature) were associated with worse prognosis among patients with aSAH [ 119 ]. In a retrospective study of 997 patients with SAH, Kurtz et al found that many non-survivors significantly experienced SIRS during hospitalization (42% of survivors vs. 63% of non-survivors, p < 0.001) [ 74 ].…”

Adipose tissue is a predictor of 30-days mortality in patients with bloodstream infection caused by carbapenem-resistant Klebsiella pneumoniae&nbsp;

“…Besides, based upon the multivariable analysis, the SOFA score, served to monitor daily organ dysfunction, and age were also signi cant indicators of the risk factors for these severe di cult-to-treat infections. SOFA score was considered as an effective and applicable prediction in hospital all-cause mortality among infectious patients caused by multidrug-resistant enterobacteria [26]. The higher of SOFA score, the more organ (respiratory, renal, neurological, renal and cardiovascular) dysfunction, which was not conducive to the patient's recovery and contributed to the increase of mortality [27].…”

The value of comorbidities and illness severity scores as prognostic tools for early outcome estimation in patients with aneurysmal subarachnoid hemorrhage

“…Aneurysmal subarachnoid hemorrhage (aSAH) is a severe cerebrovascular disease regularly accompanied by a systemic reaction and subsequently compromising not only the brain function but also the function of multiple organ systems, which in turn may influence the outcome of aSAH patients as well [ 5 , 11 , 26 ]. Considering this, aSAH rather represents a multisystemic disease requiring a comprehensive multimodal management for preservation of organ functions than a disorder restricted to the brain.…”