Systemic sclerosis prevalence and mortality in Sydney 1974‐88

Englert, H.; Small-McMahon, J.; Davis, Kevin; O’Connor, Helen M.; Chambers, P.; Brooks, Peter

doi:10.1111/j.1445-5994.1999.tb01587.x

Cited by 55 publications

(46 citation statements)

References 11 publications

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“…Those investigators estimated the point prevalence of SSc to be 233 cases per million (based on 348 cases), with an annual incidence of 16 cases per million. In contrast, a lower prevalence of SSc was reported in the Australian city of Sydney (state of New South Wales) (86 cases per million for 1988) (38). Reasons for the difference between these 2 adjacent regions are not clear.…”

Section: Discussionmentioning

confidence: 91%

Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population

Mayes¹,

Lacey²,

Beebe‐Dimmer³

et al. 2003

Arthritis & Rheumatism

835

491

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Objective. To estimate the prevalence, incidence, survival, and disease characteristics of systemic sclerosis (SSc) in the Detroit tricounty area.Methods. A census of SSc cases for the period 1989-1991 was conducted in the Detroit area, using multiple sources for case identification. Diagnoses were verified by medical record review. Capture-recapture analysis was used to estimate the total SSc population. Cases of localized scleroderma (morphea and linear disease) were excluded.Results. Based on 706 verified cases of SSc, prevalence was initially estimated to be 242.0 cases per million adults (95% confidence interval [95% CI] 213-274), with an annual incidence of 19.3 new cases per million adults per year (95% CI 12.4-30.2). Capturerecapture analysis, based on the degree of overlap of verified cases among multiple sources, resulted in a revised prevalence estimate of 276 cases per million adults (95% CI 245-310). Sex-and race-specific prevalence estimates were significantly higher for women than for men, and for blacks than for whites. The average age at diagnosis was significantly younger for blacks than for whites. Compared with white patients, black patients were almost twice as likely to have diffuse disease (prevalence proportion ratio 1.86, 95% CI 1.48-2.35). Median survival was ϳ11 years. Factors negatively affecting survival included male sex (hazard ratio 1.81, 95% CI 1.29-2.55) and older age at diagnosis (hazard ratio 1.04, 95% CI 1.03-1.05).Conclusion. This study establishes baseline estimates of SSc occurrence and characteristics in a large US cohort consisting primarily of black adults and white adults. These data should facilitate research regarding the role of geographic, ethnic, racial, and environmental factors for this disease in comparison populations.

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Section: Discussionmentioning

confidence: 91%

Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population

Mayes¹,

Lacey²,

Beebe‐Dimmer³

et al. 2003

Arthritis & Rheumatism

835

491

View full text Add to dashboard Cite

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“…Attribution bias in the manner in which death certificates are completed may be another explanation for our observation. However, methodological research suggests that while death certificate data tend to underestimate SSc mortality the bias is likely to be constant over time [23].…”

Section: Discussionmentioning

confidence: 98%

Systemic Sclerosis Mortality in the United States: 1979–1998

Krishnan

Fürst

2005

Eur J Epidemiol

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The US national mortality rates from systemic sclerosis (SSc) have not been reported since 1979. We studied age, gender and race specific time trends in US national mortality rates of SSc during the period 1979-1998 using poisson regression models. Over the 4.93 billion person-years of observation during the study period, there were 18,126 deaths from SSc, representing a mortality rate of 3.9 per million. The age adjusted mortality rates for men and women were 1.9 and 5.4 per million respectively. There were relatively few deaths in the extremes of age. SSc mortality rates increased with age in both genders and in all racial groups (p<0.001). In multivariable models adjusted for two-way statistical interactions, being African-American, female and of older age were associated with higher death rates. Over the 20 years of observation, overall (age-adjusted) SSc mortality rates showed a 36% increase (p<0.001) and subgroup analyses revealed that the increases were confined to women of both races. This rise occurred during a period in which post-diagnosis survival of SSc is known to have increased, suggesting an increasing incidence of this disease.

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“…In three, the strategy applied is in conflict with the ICD coding instructions for selecting the underlying cause of death that will appear in the mortality statistics. In two further cases, classification examples are provided that are in conflict with the ICD instructions [25,26]. None of the studies using classification principles other than those of the ICD point out this fact, or discuss why the international conventions have not been applied.…”

Section: Identifying a Principal Cause Of Death (Table 3)mentioning

confidence: 95%