Systemic sclerosis patients with and without pulmonary arterial hypertension: a nailfold capillaroscopy study

Riccieri, Valeria; Vasile, Massimiliano; Iannace, Nicoletta; Stefanantoni, Katia; Sciarra, Iliana; Vizza, Carmine Dario; Badagliacca, Roberto; Poscia, Roberto; Papa, Silvia; Mezzapesa, Mario; Nocioni, Martina; Valesini, Guido

doi:10.1093/rheumatology/ket168

Cited by 73 publications

(92 citation statements)

References 11 publications

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“…However, Hofstee et al [15] found it lower in SSc patients with PAH than those without it. On the other hand, Riccieri et al [16] found that the presence of avascular area was associated with PAH in SSc patients compared to those without it. Also, Ong et al [17] stated that reduced capillary density was associated with PAH and there might be a pathogenic and etiologic relationship between them.…”

Section: Discussionmentioning

confidence: 99%

Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

Shenavandeh¹,

Haghighi²,

Nazarinia³

2017

Reumatologia

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BackgroundSystemic sclerosis (SSc) is a chronic disease with microvascular damage. Nailfold capillaroscopy is a non-invasive method used for evaluating capillaries in SSc. Its findings could be related to the internal organ involvement and SSc course. In this study, we aimed to determine the association of the capillaroscopic patterns of nailfold capillaries with the disease subtypes of SSc, disease duration, and clinical manifestations.Material and methodsSeventy patients with SSc (15 cases with diffuse cutaneous SSc [DcSSc] and 55 patients with limited SSc [LcSSc]) were studied. The patients were classified into early and intermediate/late DcSSc and LcSSc regarding their disease duration. The capillaroscopy findings were classified into normal, ‘early’, ‘active’ and ‘late’ scleroderma patterns, and ‘non-specific’ changes. The association of the nailfold capillaroscopy changes and their components with clinical manifestations was also studied.ResultsWe studied 15 DcSSc and 55 LcSSc patients. No association was found between the patterns of capillaroscopic changes and these subtypes. There were 8 early DcSSc, 7 intermediate/late DcSSc, 34 early LcSSc, and 21 intermediate/late LcSSc patients. In patients with LcSSc, the ‘early’ scleroderma pattern of capillaroscopy was associated with early disease based on duration. We found a direct association between some capillary components and some clinical findings. Also, some capillaroscopic components had an inverse association with some clinical manifestations.ConclusionsWe found no association between the patterns of capillaroscopy and SSc subtypes; early scleroderma pattern of capillaroscopy was significantly associated with early LcSSc, compatible with the slower course of the disease in LcSSc. Subtle changes, capillary elongation, and capillary tortuosity had an inverse association with clinical manifestations and might be considered as good prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

Shenavandeh¹,

Haghighi²,

Nazarinia³

2017

Reumatologia

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“…A few studies suggest that patients with PAH have systemic vascular dysfunction when compared with control subjects as determined by forearm blood flow dilation after brachial artery occlusion (15,16). A study in a small number of patients with systemic sclerosis reported that the nailfold microvasculature is significantly more affected in individuals who had PAH when compared with those who did not (17). However, no study to date has evaluated the microvasculature at the level of the sublingual mucosa in patients with PAH.…”

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confidence: 99%

Sublingual Microcirculation in Pulmonary Arterial Hypertension

et al. 2014

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“…In fact, previous studies never compared microangiopathy changes with the clinical aspect of disease, in particular DU. Moreover, no patient in our study was affected by pulmonary arterial hypertension, a possible confounding factor in analysis of results on both clinical and NVC effects [39]. Another possible limitation was the observational nature of the study, that could introduce a number of biases, e.g.…”

Section: Discussionmentioning

confidence: 94%

Effect of treatment with iloprost with or without bosentan on nailfold videocapillaroscopic alterations in patients with systemic sclerosis

Cestelli

Manfredi

Sebastiani

et al. 2016

Modern Rheumatology

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Systemic sclerosis patients with and without pulmonary arterial hypertension: a nailfold capillaroscopy study

Cited by 73 publications

References 11 publications

Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

Sublingual Microcirculation in Pulmonary Arterial Hypertension

Effect of treatment with iloprost with or without bosentan on nailfold videocapillaroscopic alterations in patients with systemic sclerosis

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