Systemic sclerosis in Asians: Are there racial differences?

Ng, Sue‐Ann; Low, Andrea

doi:10.1177/23971983221074749

Cited by 7 publications

(10 citation statements)

References 53 publications

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“…However, other studies reported a higher proportion of lcSSc in their studies [38,41]. Recently, a study among Asian SSc patients found that Asian patients have a distinct genetic susceptibility to systemic sclerosis, earlier systemic sclerosis onset, more diffuse skin involvement, and a more severe clinical phenotype [42]. This dissimilarity of the results might be due to the geo-epidemiological differences in studies.…”

Section: Discussionmentioning

confidence: 89%

“…A study conducted in Italy found that 100% had antinuclear antibodies, 37.5% had anti-topoisomerase antibodies, and 37.5% had anticentromere antibodies [41]. On the other hand, an Asian study documented 85.5% antinuclear antibody and 22.7% anticentromere antibody-positive patients [42].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, multiple genetic and/or environmental factors may also produce specific autoantibodies [43]. Moreover, a study reported that Asian patients have different autoantibody profiles higher frequency of anti-Scl70 and anti-U1-RNP antibodies [42].…”

Section: Clinical Manifestations Physical Component Summary Mental Co...mentioning

confidence: 99%

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Functional disability and health-related quality of life among systemic sclerosis patients in Bangladesh

et al. 2022

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Objective To assess the relationship between functional disability and health-related quality of life (HRQoL) among systemic sclerosis (SSc) patients. Methodology This cross-sectional study was carried out on 78 adults who met the classification criteria for SSc defined by the American College of Rheumatology/European League of Rheumatology (ACR/EULAR)-2013. The Bangla version of Short Form 36 (SF-36) and Health Assessment Questionnaire-Disability Index (HAQ-DI) were used to measure HRQoL and functional disability in SSc patients. Results The patients' median [IQR] HAQ-DI was 1.4 [0.6–2.1], with 37.2% having a mild functional disability, 33.3 percent having a moderate functional disability, and 29.5 percent having a severe functional disability. The hygiene and activity domains of the HAQ-DI obtained the highest scores, 2.0 [0.0–3.0] and 2.0 [1.0–3.0], respectively. The Physical Component Summary (PCS) and Mental Component Summary (MCS) of the SF-36 had median [IQR] values of 26.2 [15.0–58.1] and 42.0 [19.6–60.6]. The highest score was 50.0 [25.0–75.0] in social functioning. The PCS of the SF-36 was moderately correlated with the HAQ-DI (rs = − 0.629, P < 0.001) and the MCS of the SF-36 was weakly correlated with the HAQ-DI ((rs = − 0.344, P < 0.001). Age, female sex, and incomplete fist closure substantially influenced functional status. Calcinosis, Raynaud's Phenomenon, and flexion contracture significantly diminished the quality of life. Conclusions Functional disability negatively affects health-related quality of life. Age, Musculoskeletal, and skin involvement are significantly associated with poor quality of life and functional disability. Therefore, treatment strategies should be aimed at reducing functional disability, which will enhance the HRQoL of SSc patients.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Functional disability and health-related quality of life among systemic sclerosis patients in Bangladesh

et al. 2022

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“…This could be explained by the low frequency or low titres of these antibodies [ 26–28 ], which might prevent their detection by immunodot. It could be also attributed to other ethnic and environmental factors, even in the same Caucasian ethnicity [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and serological correlation of systemic sclerosis in Moroccan patients

Ouazahrou

Bakkouri

Souali

et al. 2023

Rheumatology Advances in Practice

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Objective Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive fibrosis of the skin and internal organs, along with microvascular damage, and is often associated with typical autoantibodies. This study aimed to analyze the correlation between specific autoantibody profiles, clinical and paraclinical features in Moroccan patients with SSc. Methods We analyzed the presence of specific autoantibodies in 46 SSc patients using indirect immunofluorescence (IIF) on Hep-2 cells and immunodot. We then correlated the type of autoantibodies with clinical and laboratory manifestations. Results Among our patients, 86.9% were females. The mean age of patients at diagnosis was 50.21 years old, with an average diagnosis delay of 5 years. The main clinical manifestations found were Raynaud’s phenomenon (89.2%), sclerodactyly (84.8%), proximal scleroderma (67.4%), gastrointestinal involvement (50%), and interstitial lung disease (30.4%). According to the specific autoantibody profile, 14 patients were anti-topo I positive (30.4%), 8 were anti-RNP(68kDa/A/C) positive (17.4%) and 6 were anti-RNA polymerase III positive (13%). We found a significant association of Anti-RNAP III with sclerodactyly and pulmonary arterial hypertension (p < 0.05). We also found an association between anti-topo I and interstitial lung disease in 30.4% of patients. There was no significant association between the positivity for the autoantibodies and other diagnosed clinical manifestations. Conclusion Some clinical manifestations of SSc may correlate positively with the presence of specific autoantibodies. Environmental factors, ethnicity, and gene interaction may also influence this correlation. Lay summary What does this mean for patients? Systemic sclerosis (SSc) is a disease that affects the connective tissues, causing excessive skin and internal organs fibrosis and microvascular damage. Specific autoantibodies, which are antibodies that attack the body's tissues, are responsible for amplifying the immune response and targeting cells involved in the development of SSc. This study aimed to investigate the relationship between specific autoantibodies and the clinical and laboratory features of SSc in 46 Moroccan patients. The majority of patients were female, middle-aged, and of Caucasian ethnicity, with a mean age of 50 years, and duration of disease between 1 and 10 years. The most common symptoms were Raynaud’s phenomenon (89.2% of patients), sclerodactyly (84.8%), proximal scleroderma (67.4%), gastrointestinal involvement (50%), arthralgia (41.3%), interstitial lung disease (30.4%), myalgia (24%) and pulmonary arterial hypertension (10.8%). We found a correlation between anti-RNAP III and Sclerodactyly and pulmonary arterial hypertension, while anti-topo I autoantibodies were associated with interstitial lung disease. The study also noted that environmental factors, ethnicity, and genetic interactions may influence the clinical and autoantibody profile in SSc patients.

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“…In particular, patients of African descendance experience a higher incidence of the disease, earlier onset, more end-organ disease, lower quality of life, and higher mortality than White patients (8,11). Compared to White patients, Asian patients have a high prevalence of anti-topoisomerase I, anti-U1 RNP antibodies, interstitial lung disease, an earlier disease onset, and develop a scleroderma renal crisis less commonly (12). Studies in Asia have also highlighted differences in disease severity across different regions, with the diffuse cutaneous subset being more prevalent in Thailand, China, and India (13,14), in contrast with what is observed in Japan, Korea, and Iran (15,16).…”

Section: Introductionmentioning

confidence: 99%

Reporting and Representativeness of Race, Ethnicity, and Socioeconomic Status in Systemic Sclerosis Randomized Trials: An Observational Study

Chaix

Mongin

Gabay

et al. 2023

Arthritis Care & Research

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To assess how and to what extent socioeconomic status and ethnicity/race of participants are reported in randomized controlled trials (RCTs) on systemic sclerosis (SSc), and to estimate the representativeness of different ethnic/racial groups in SSc RCTs.Methods. We searched all published RCTs on SSc indexed in PubMed. We retrieved information on main features of RCTs published from 2000 onward and recorded for each study whether race/ethnicity was reported; how ethnicity/ race was defined and assigned; and the number of patients included for each racial/ethnic group. Multivariable logistic regression was used to identify factors associated with race/ethnicity reporting. Proportion of races/ethnicities included in US-based RCTs on SSc was examined and compared with US demographic data.Results. We included 106 studies, mostly conducted in Europe (42%) or North America (25%), published after 2010 (74%), and enrolling a total of 6,693 patients. About one-third of studies provided information about race/ethnicity, with no improved reporting over time. Only 2 papers reported patient's socioeconomic status. Study location (US or intercontinental) was the only significant factor associated with a better reporting of race/ethnicity in multivariable analysis. In studies where race/ethnicity was reported, White patients were mostly represented (79%), followed by Asian (7%), and African American (6%). In the sensitivity analysis limited to studies from the US, underrepresentation of African American patients was observed in the 2000-2010 time period, but not later.Conclusion. Documentation of race/ethnicity and socioeconomic status is poor in RCTs on SSc. More effort should be made to document race/ethnicity and socioeconomic status and to promote diversity in SSc RCTs.

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Systemic sclerosis in Asians: Are there racial differences?

Cited by 7 publications

References 53 publications

Functional disability and health-related quality of life among systemic sclerosis patients in Bangladesh

Functional disability and health-related quality of life among systemic sclerosis patients in Bangladesh

Clinical and serological correlation of systemic sclerosis in Moroccan patients

Reporting and Representativeness of Race, Ethnicity, and Socioeconomic Status in Systemic Sclerosis Randomized Trials: An Observational Study

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