Systemic sclerosis in a patient with pityriasis rubra pilaris

Frikha, F.; Frigui, M.; Masmoudi, Hatem; Turki, H.; Bahloul, Z.

doi:10.4314/pamj.v6i1.69070

Cited by 4 publications

(2 citation statements)

References 26 publications

(34 reference statements)

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“…Radiographic evidence of acro-osteolysis is frequently described although only two cases of erosive arthritis have been reported [53,59]. Other rheumatological associations with PRP include myositis (specifically dermatomyositis and Wong-type dermatomyositis, with skin lesions characterized by the grouped keratotic follicular papules of PRP) [63,64], autoimmune thyroiditis [60], celiac sprue [65], systemic sclerosis [66] and myasthenia gravis [67].…”

Section: Pityriasis Rubra Pilarismentioning

confidence: 99%

Beyond plaque psoriasis – pathogenesis and treatment of other psoriasis phenotypes

Iznardo

Puig

2022

Current Opinion in Rheumatology

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Purpose of reviewPsoriasis vulgaris is the commonest presentation of psoriatic disease, but morphologic variants such as pustular psoriasis (PP) and a closely related disease, pityriasis rubra pilaris (PRP), have been known for a long time, have been associated with rheumatologic manifestations indistinguishable from psoriatic arthritis (PsA) that may go unrecognized, and often represent a therapeutic conundrum. There is recent evidence that underlying genetic and pathogenetic differences may provide the basis for newer therapeutic approaches.Recent findingsThis narrative review highlights the clinical, genetic and pathogenetic characteristics of PP and PRP, their association with PsA and recent developments in their treatment, especially with biologic agents targeting IL-36 and other cytokines of pathogenic relevance.SummaryThe clinical manifestations of PP and PRP are less well known to rheumatologists than those of psoriasis, and recent advances in our insight on their pathogenesis may eventually overcome the therapeutic difficulties faced by dermatologists and rheumatologists in the management of these diseases and their rheumatologic manifestations.

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Section: Pityriasis Rubra Pilarismentioning

confidence: 99%

Beyond plaque psoriasis – pathogenesis and treatment of other psoriasis phenotypes

Iznardo

Puig

2022

Current Opinion in Rheumatology

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“…2 Immune dysregulation may play a role in the pathogenesis of PRP where there is an abnormal response to antigenic triggers, lymphocyte hypersensitivity to superantigens and T-lymphocyte abnormalities. 4 In addition, given the Small T-antigen of the TS-associated polyomavirus activates factors implicated in the MAPK pathway Editor Trichodysplasia Spinulosa (TS) is a rare, disfiguring skin condition that affects immunocompromised patients. The disease is characterized clinically by a papular eruption that can progress to leonine faces or alopecia and histologically by a proliferation of nucleated granular cells and dysplasia of inner root sheath cells.…”

Section: Pityriasis Rubra Pilaris-like Eruption With Dermatomyositis mentioning

confidence: 99%

Pityriasis rubra pilaris‐like eruption with dermatomyositis and diffuse cutaneous systemic sclerosis overlap

Alcalá

Noguera‐Morel

Garulo

et al. 2015

Acad Dermatol Venereol

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2 Sudbrak R, Brown J, Dobson-Stone C et al. Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca( 2+ ) pump. Hum Mol Genet 2000; 9: 1131-1140. 3 Van Baelen K, Vanoevelen J, Callewaert G et al. The contribution of the SPCA1 Ca 2+ pump to the Ca 2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference. Biochem Biophys Res Commun 2003; 306: 430-436. 4 Dobson-Stone C, Fairclough R, Dunne E et al. Hailey-Hailey disease: molecular and clinical characterization of novel mutations in the ATP2C1 gene. J Invest Dermatol 2002; 118: 338-343. 5 Mukhopadhyay S, Linstedt AD. Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn 2+ efflux and protects against toxicity. Proc Natl Acad Sci USA 2011; 108: 858-863. 6 Fairclough RJ, Dode L, Vanoevelen J et al. Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca 2+ /Mn 2+ -ATPase (hSPCA1). J Biol Chem 2003; 278: 24721-24730. 7 Zhang D, Li X, Xiao S et al. Detection and comparison of two types of ATP2C1 gene mutations in Chinese patients with Hailey-Hailey disease. Arch Dermatol Res 2012; 304: 163-170. 8 Shibata A, Sugiura K, Kimura U et al. A Novel ATP2C1 early truncation mutation suggests haploinsufficiency as a pathogenic mechanism in a patient with Hailey-Hailey disease. Acta Derm-Venereol 2013; 93: 719-720. 9 Wu Y, Xing X, Xu S et al. Novel and recurrent mutations in the EXT1 and EXT2 genes in Chinese kindreds with multiple osteochondromas.

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Pseudoainhum in a Case of Pityriasis Rubra Pilaris- A Rare Case Report

Rajalakshmi¹,

Ramanathan²,

Balasubramanian³

2017

jemds

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BACKGROUNDConstriction bands around the digits are termed as ainhum; those which mimic ainhum are termed as pseudoainhum. Ainhum and pseudoainhum can cause autoamputation of the digits. Ainhum which is of idiopathic origin is common in Negros, but rare in rest of the world. Many hypotheses were promulgated for the aetiology of pseudoainhum; however, it has been associated with hereditary palmoplantar keratodermas, systemic sclerosis, leprosy, psoriasis, vascular anomalies etc. We report a case of pseudoainhum associated with pityriasis rubra pilaris (PRP), which has not been reported in the literature so far.

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Systemic sclerosis in a patient with pityriasis rubra pilaris

Cited by 4 publications

References 26 publications

Beyond plaque psoriasis – pathogenesis and treatment of other psoriasis phenotypes

Beyond plaque psoriasis – pathogenesis and treatment of other psoriasis phenotypes

Pityriasis rubra pilaris‐like eruption with dermatomyositis and diffuse cutaneous systemic sclerosis overlap

Pseudoainhum in a Case of Pityriasis Rubra Pilaris- A Rare Case Report

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