Systemic Sclerosis and the Heart

Parks, John L.; Taylor, Marian H; Parks, Laura P.; Silver, Richard M.

doi:10.1016/j.rdc.2013.10.007

Cited by 65 publications

(63 citation statements)

References 61 publications

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“…Cardiac involvement in SSc is classified into primary and secondary cardiac involvement, which is related to pulmonary artery hypertension or scleroderma renal crisis. Primary cardiac involvement is common in SSc and can affect the pericardium, vascular, conducting system, and myocardium . According to autopsies, the hallmark of myocardial involvement in SSc is patchy myocardial fibrosis, which is detected at the late stage of the disease during which there is no specific treatment that can improve cardiac outcome .…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory predictions of myocardial inflammation as detected by cardiac magnetic resonance imaging in patients with systemic sclerosis: A pilot study

et al. 2019

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Background: Cardiac magnetic resonance imaging (cardiac MRI) has high sensitivity and specificity for differentiating cardiac fibrosis from inflammation. There is no data on the clinical and laboratory association or prediction of myocardial inflammation in systemic sclerosis-a major organ involvement in systemic sclerosis (SSc). Objectives:Our aim was to ascertain the clinical and laboratory associations with myocardial inflammation in SSc patients as detected by cardiac MRI.

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Section: Introductionmentioning

confidence: 99%

Clinical and laboratory predictions of myocardial inflammation as detected by cardiac magnetic resonance imaging in patients with systemic sclerosis: A pilot study

et al. 2019

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“…Conduction system alterations are present in about 20% of patients,15 and right bundle branch block has been recently described to be an independent predictor of mortality in this group 16…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac conduction system was also involved in this patient, and she had electrocardiographic evidence of intraventricular conduction disturbance with bifascicular block pattern. Conduction system alterations are present in about 20% of patients, 15 and right bundle branch block has been recently described to be an independent predictor of mortality in this group. 16 Prognosis of SSc patients with CI seems worse, particularly when it becomes clinically evident.…”

Section: Autoimmune Myocarditis In Systemic Sclerosismentioning

confidence: 98%

Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation

et al. 2017

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Primary cardiac involvement in systemic sclerosis is common, often subclinical, and is associated with significant mortality. We report the case of a patient who developed autoimmune myocarditis at an early stage of systemic sclerosis, who completely recovered from cardiac dysfunction under optimal medical therapy for heart failure and immunosuppression. This challenging case aims at increasing awareness around the fact that the heart is a target organ of scleroderma disease. It also highlights the importance of screening and early diagnosis of cardiac involvement, because a timely treatment may impact the quality of life of these patients and improve their prognosis.

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“…Significant cardiovascular involvement in SSc indicates a poor prognosis [13]. While there is well established data regarding atherosclerosis and cardiovascular risk factors in RA and SLE [2,14], there is growing evidence that accelerated atherosclerosis occurs in SSc.…”

Section: Discussionmentioning

confidence: 99%

Carotid Intima Media Thickness in Systemic Sclerosis Patients: Results From a Single Centre, Cross Sectional, Case-Control Study

Sharma¹,

Mohamed²,

Prakash³

et al. 2017

Angiol

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Objective: To describe the parameters of subclinical vascular changes [Carotid Intima Media Thickness (cIMT), Flow Mediated Dilatation (FMD), Ankle Brachial Pressure Index (ABPI)] in patients with systemic sclerosis and compare them with age and sex matched controls.Methods: 50 patients of systemic sclerosis aged 20-50 years were selected and compared with the same no. of age and sex matched controls. Patients with diabetes, hypertension, dyslipidemia, smoking and thyroid disorders were excluded. cIMT, FMD and ABPI were calculated for all participants.

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Systemic Sclerosis and the Heart

Cited by 65 publications

References 61 publications

Clinical and laboratory predictions of myocardial inflammation as detected by cardiac magnetic resonance imaging in patients with systemic sclerosis: A pilot study

Clinical and laboratory predictions of myocardial inflammation as detected by cardiac magnetic resonance imaging in patients with systemic sclerosis: A pilot study

Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation

Carotid Intima Media Thickness in Systemic Sclerosis Patients: Results From a Single Centre, Cross Sectional, Case-Control Study

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