Systemic Sclerosis and Silicone Breast Implant: A Case Report and Review of the Literature

Psarras, Antonios; Gkougkourelas, Ioannis; Tselios, Konstantinos; Sarantopoulos, Alexandros; Boura, Panagiota

doi:10.1155/2014/809629

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…4 Exposure to various environmental factors such as polyvinyl chloride and silica has been thought to play a role in the development of the disease. 3,6 Therefore, silicone breast implants (SBI) have been suggested as a cause for a range of autoimmune diseases including SSc, even if a definite relationship between the two conditions has not yet been conclusively proven, [6][7][8][9] mostly due to a lack of consistent estimates and adequate adjustment for potential confounders. 3,7 However, research among the literature reveals several SSc case reports following SBI.…”

Section: Introductionmentioning

confidence: 99%

“…3,6 Therefore, silicone breast implants (SBI) have been suggested as a cause for a range of autoimmune diseases including SSc, even if a definite relationship between the two conditions has not yet been conclusively proven, [6][7][8][9] mostly due to a lack of consistent estimates and adequate adjustment for potential confounders. 3,7 However, research among the literature reveals several SSc case reports following SBI. 7,[10][11][12][13][14] The SSc-related autoantibodies that are detectable with commercially available enzyme-linked immunosorbent assay kits (ELISAs) are anti-topoisomerase I (Topo-I), anti-centromere antibody (ACA) and anti-RNA polymerase III (RNAP III).…”

Section: Introductionmentioning

confidence: 99%

“…3,7 However, research among the literature reveals several SSc case reports following SBI. 7,[10][11][12][13][14] The SSc-related autoantibodies that are detectable with commercially available enzyme-linked immunosorbent assay kits (ELISAs) are anti-topoisomerase I (Topo-I), anti-centromere antibody (ACA) and anti-RNA polymerase III (RNAP III). 15 SSc patients with RNAP III positivity are thought to be associated with diffuse cutaneous involvement, renal crisis and malignancies concomitant to SSc onset, 16 particularly breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“… 3 , 7 However, research among the literature reveals several SSc case reports following SBI. 7 , 10 – 14 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

<p>Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review</p>

Angelis

Battista

Smerilli

et al. 2020

OARRR

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Some case reports and small case series of patients with silicone breast implant (SBI) have reported the development of systemic sclerosis (SSc) many years later, despite conflicting evidence of this association in the literature. Recently, patients with SSc and anti-RNA polymerase III antibodies positivity have been associated with previous silicone implants and/or breast cancer, showing clinical features that differ from the classic SSc, such as rapid and diffuse cutaneous involvement and scleroderma renal crisis (SRC). The specific autoimmune reaction is not yet fully understood, although knowledge in this regard is increasing. We describe a case that can support these previous observations, strengthening this association which must be taken into account. Clinicians should be aware of this new clinical entity, given the widespread use of silicone implants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 3 , 7 However, research among the literature reveals several SSc case reports following SBI. 7 , 10 – 14 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review</p>

Angelis

Battista

Smerilli

et al. 2020

OARRR

View full text Add to dashboard Cite

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Systemic sclerosis with anti-RNA polymerase III positivity following silicone breast implant rupture: possible role of B-cell depletion and implant removal in the treatment

Dall’Ara

Lazzaroni

Antonioli³

et al. 2017

Rheumatol Int

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Despite some case reports and small series of women with silicone breast implants (SBI) developing Systemic Sclerosis (SSc), no clear evidence of an association of SBI with SSc is available. However, SSc is characterized by clinical and immunological heterogeneity and autoantibodies are currently the best markers to stratify this heterogeneity of patients. Therefore, we have reviewed the literature for details of autoantibody characterization in reports of SSc associated with SBI. Moreover, the case of an anti-RNA polymerase III-positive SSc with rapid onset and progression, in which SBI rupture was found is described. This case may support a previous observation suggesting a possible role of SBI rupture as a trigger for anti-RNA polymerase III-positive SSc. This possible causal role may be reinforced by the observation that in our patient, despite immunosuppressive treatment, the disease progressed until SBI were removed, and reduction of anti-RNA polymerase III titer was obtained after rituximab treatment. This result may support data suggesting that B-cell depleting therapy may decrease specific autoantibody level in SSc patients, and that these changes are associated with disease improvement.

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Women with silicone breast implants and autoimmune inflammatory syndrome induced by adjuvants: description of three patients and a critical review of the literature

Pavlov-Dolijanovic

Stupar

2017

Rheumatol Int

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Silicone has been widely used in the manufacture of medical implants. It is well tolerated in most cases. However, in this paper we report the cases of three women who developed autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), namely with silicone breast implants. The symptoms in these cases include arthralgia, arthritis, myalgia, sleep disturbances, the appearance of autoantibodies, miscarriage, Raynaud's phenomenon, and involvement of autoimmune diseases (scleroderma and undifferentiated connective tissue diseases). In one patient, breast implants were removed, but no improvement was seen after the removal. The remaining two patients received the updated information about their condition, and they decided not to remove the implants. In conclusion, earlier reports that silicone is biologically relatively inert have recently been challenged with the description of ASIA syndrome.

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Systemic Sclerosis and Silicone Breast Implant: A Case Report and Review of the Literature

Cited by 3 publications

References 19 publications

<p>Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review</p>

<p>Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review</p>

Systemic sclerosis with anti-RNA polymerase III positivity following silicone breast implant rupture: possible role of B-cell depletion and implant removal in the treatment

Women with silicone breast implants and autoimmune inflammatory syndrome induced by adjuvants: description of three patients and a critical review of the literature

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