Systemic Sclerosis and Exposure to Trichloroethylene

Czirják, L.; Schlammadinger, J; Szegedi, G

doi:10.1159/000247355

Cited by 18 publications

(4 citation statements)

References 2 publications

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“…Saihan et al (1978) reported scleroderma, pigmentation, and Raynaud's phenomenon in a middle-aged man following prolonged exposure to TCE. Other cases of progressive systemic sclerosis also have been reported as being TCE-induced (Yamakaga and Ishikawa, 1982;Haustein and Ziegler, 1985;Czirjak et al, 1989Czirjak et al, , 1993Fleming et al, 1991;Perry, 1994;Yanez et al, 1992).…”

Section: Gastrointestinal Effectsmentioning

confidence: 97%

“…White corn wet-milling workers exposed to solvents and other chemicals experienced excess mortality from lymphatic and hematopoietic malignancies (Thomas et al, 1985). Other hematological effects reported following TCE exposure include: thrombocytopenia (Czirjak et al, 1993); microangiopathic hemolytic anemia (Lockey et (Walder, 1983); and &dquo;low blood counts&dquo; (Kilburn and Warshaw, 1992). In contrast, Stewart et al (1970) reported that acute exposures to TCE resulted in no adverse hematological effects on blood cell counts, sedimentation rates, serum lipid levels, serum proteins, or serum enzymes.…”

Section: Ethanol Consumptionmentioning

confidence: 99%

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Trichloroethylene — a Review of the Literature From a Health Effects Perspective

Gist

Burg

1995

Toxicol Ind Health

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This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries--persons with documented exposure to TCE through drinking and use of contaminated water. The health effects reported in excess by some or all of the sex and age groups studied were speech and hearing impairments, effects of stroke, liver problems, anemia and other blood disorders, diabetes, kidney disease, urinary tract disorders, and skin rashes.

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Section: Gastrointestinal Effectsmentioning

confidence: 97%

Section: Ethanol Consumptionmentioning

confidence: 99%

Trichloroethylene — a Review of the Literature From a Health Effects Perspective

Gist

Burg

1995

Toxicol Ind Health

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“…An exposure to aliphatic or hydrocarbon solvents, including trichloroethylene, perchloroethylene, toluene, benzene and xylene, and also white spirits, diesel and aromatic mixes, seems to be an important provoking factor for scleroderma-related disorders in different parts of the world [1,[3][4][5][6][7][8][9][10][11][12], including Hungary [5,6,[13][14][15]. Among the solvents trichloroethylene is a considerable provoking factor [6,9,10,13,[16][17][18]. Other agents, such as perchloroethylene, benzene [6,14], other organic compounds including amines [4], and formaldehyde derivatives [4] are also capable of provoking scleroderma.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Solvents in Female Patients with Scleroderma

Czirják

Kumánovics

2002

Clin Rheumatol

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The role of exposure to solvents was investigated in female patients with connective tissue disease and Raynaud's phenomenon using a questionnaire. Sixteen out of the 63 patients with systemic sclerosis had been exposed to solvents. A borderline significance was demonstrated compared to matched female controls (P < 0.05). Fourteen out of the 66 patients with undifferentiated connective tissue disease, 18/86 of patients with Raynaud's phenomenon, 6/45 with systemic lupus erythematosus, 1/16 with dermatopolymyositis, 1/15 with rheumatoid arthritis and 0/13 with primary Sjögren's syndrome had been exposed to solvents. None of these groups of patients showed a statistical significance compared to matched controls. Our present findings indicate that, at least in certain areas of the world, exposure to solvents may be a provoking factor in female scleroderma, but it must be emphasised that only a borderline significance was found between the scleroderma patients and controls. A large multicenter study seems to be required to clarify the importance of solvents as provoking factors of scleroderma. Furthermore, exposure to solvents does not seem to be a provoking factor among females for the other connective tissue diseases.

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“…Garcia-Zamalloa et al [28] reported a case of SSc following 23 years of employment in a tire factory where there was potential for exposure to toluene, heptane, dimethylbutylphenyldiamine, and octaphenol formaldehyde. Czirjak et al [29] reported a case in a woman who was chronically exposed specifically to trichloroethylene in the workplace. Following 3 years of exposure, she developed Raynaud's phenomenon, acrosclerosis, and joint symptoms.…”

Section: Systemic Sclerosis and Sclerodermamentioning

confidence: 99%

Untitled

Garabrant

Dumas

2000

Arthritis Res

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Case reports suggest that solvents are associated with various connective tissue diseases (systemic sclerosis, scleroderma, undifferentiated connective tissue disease, systemic lupus erythematosis, and rheumatoid arthritis), particularly systemic sclerosis. A small number of epidemiological studies have shown statistically significant but weak associations between solvent exposure, systemic sclerosis, and undifferentiated connective tissue disease. However, the interpretation of these positive findings is tempered by a lack of replication, an inability to specify which solvents convey risk, and an absence of increasing risk with increasing exposure. Existing studies, on aggregate, do not show conclusively that solvents (either as a group of chemicals or individual chemicals) are causally associated with any connective tissue disease. Further investigations should be carried out to replicate the positive existing findings and to specify the solvents and circumstances of exposure that carry risk. The electronic version of this article can be found online at http://arthritis-research.com/content/2/1/005 © Current Science Ltd CI = confidence interval; HLA = human leukocyte antigen; OR = odds ratio; SLE = systemic lupus erythematosus; SSc = systemic sclerosis; UCTD = undifferentiated connective tissue disease.

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Systemic Sclerosis and Exposure to Trichloroethylene

Cited by 18 publications

References 2 publications

Trichloroethylene — a Review of the Literature From a Health Effects Perspective

Trichloroethylene — a Review of the Literature From a Health Effects Perspective

Exposure to Solvents in Female Patients with Scleroderma

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