Systemic review on drug related hospital admissions – A pubmed based search

Nivya, Kolli; Kiran, Vempati Sri Sai; Ragoo, Nandita; Jayaprakash, B; Sekhar, M. Sonal

doi:10.1016/j.jsps.2013.05.006

Cited by 94 publications

(81 citation statements)

References 19 publications

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“…In fact, using a too sensitive search strategy can result in many redundant hits and initially increase the researcher's workload. However, our number of hits was consistent more with that of a recent systematic review on drug related hospital admission, made using PubMed by Nivya et al covering the period between 2007-2013, and they found only (366) initial hits [5].…”

supporting

confidence: 91%

Reply to the letter regarding ‘A systematic review of hospitalization resulting from medicine related problems in adult patients’

Hamid

Ghaleb

Aljadhey

et al. 2014

Brit J Clinical Pharma

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supporting

confidence: 91%

Reply to the letter regarding ‘A systematic review of hospitalization resulting from medicine related problems in adult patients’

Hamid

Ghaleb

Aljadhey

et al. 2014

Brit J Clinical Pharma

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“…The most age was represented the eighty-eight percent of responders. There is no statistically significant between all age categories between patient and healthcare professionals expert in the age (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) years. The complete most healthcare professionals were pharmacist 34 (65.38%), and nurses were six (11.54%) followed by others 5 (9.62%), dentist 4 (7.69%) and 3 (5.77%) physicians.…”

Section: Resultsmentioning

confidence: 99%

Clinical Outcomes of Drug-related Problems in Saudi Arabia: Patients’ and Healthcare Providers’ Perspective

Alomi¹,

Al-Shaibani²,

Alfaisal³

et al. 2018

JPPCM

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“…However, the frequency of DRMs has varied widely from 0.2% to 65% in individual studies (38,40,41), due to differing study designs and settings, study populations, and detection methods of DRMs (39,42). Moreover, DRMs are found more often among the elderly and persons with multiple medications (38,(43)(44)(45).…”

Section: Drug-related Morbiditiesmentioning

confidence: 99%

Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

Hedna

2015

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Aim:The aim of this thesis is to estimate and analyse the burden of potentially inappropriate prescriptions (PIPs) in the elderly and non-adherence to long-term medications among adults across care settings, and to investigate how IUM is associated to DRMs. Methods:A meta-analysis summarised the previous evidence on the percentage of adverse drug reactions (ADRs) associated to IUM across healthcare settings (Study I). From a cohort in the general population, using medical records and register data, the prevalence of PIPs in the elderly and its association with ADRs were estimated retrospectively (Study II). From the same cohort, the factors associated with refill non-adherence to antihypertensive therapy, considering the use of multiple medications, and the association between non-adherence and sub-therapeutic effects (STEs) were investigated (Study III). A survey assessed the refill behaviour to antihypertensive, lipid lowering and oral antidiabetic medications (undersupply, adequate supply and oversupply), and its association with perceived ADRs and STEs (Study IV).Results: IUM was the cause 52% and 45% of ADRs occurring in adult outpatients and inpatients respectively. Across healthcare settings, 46% of the elderly refilled PIPs over a 6-month period;PIPs were considered the cause of 30% of all ADRs; and the elderly who were prescribed PIPs had increased odds to experience ADRs (OR 2.47, 95% CI 1.65-3.69). In total, 35% was nonadherent to the full multidrug therapy and 13% was non-adherent to any medication (complete vi non-adherence). Sociodemographic factors (working age and lower income) were associated with non-adherence to any medication, while clinical factors (use of specialised care, use of multiple medications, and being a new user) with non-adherence to the full multidrug therapy. STEs were associated with non-adherence to any medication a month prior to a healthcare visit (OR 3.27, 95% CI 1.27-8.49), but not with long-term measures of non-adherence. Among survey respondents, 22% of the medications were oversupplied and 12% were undersupplied. Inadequate refill behaviour was not associated with reporting ADRs or STEs (p<0.05). Conclusions:A large proportion of ADRs occurring in hospital is caused by IUM, but more knowledge is needed in other settings. PIPs are common in the elderly general population and associated with ADRs. Therefore decreasing PIPs could contribute towards ADR prevention.Considering the use of multiple medications may help to better understand the factors associated with non-adherence to a multidrug therapy for tailoring the interventions to patient needs.Monitoring the adherence prior to a healthcare visit may facilitate interpreting STEs. Yet, the absence of an association between long-term measures of refill non-adherence with clinical and perceived DRMs suggest the need to enhance the knowledge of this association in clinical practice.In summary, this thesis shows a significant potential for improvements of medication use and outcomes.Key words: Drug-related morbidity, medica...

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Systemic review on drug related hospital admissions – A pubmed based search

Cited by 94 publications

References 19 publications

Reply to the letter regarding ‘A systematic review of hospitalization resulting from medicine related problems in adult patients’

Reply to the letter regarding ‘A systematic review of hospitalization resulting from medicine related problems in adult patients’

Clinical Outcomes of Drug-related Problems in Saudi Arabia: Patients’ and Healthcare Providers’ Perspective

Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

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