2010
DOI: 10.1016/j.freeradbiomed.2010.10.363
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Systemic Remodeling of the Redox Regulatory Network due to RNAi Perturbations of Glutaredoxin, Thioredoxin, and Glucose-6-phosphate Dehydrogenase

Abstract: Background: Cellular clearance of reactive oxygen species is dependent on a network of tightly coupled redox enzymes; this network rapidly adapts to oxidative conditions such as aging, viral entry, or inflammation. Current widespread use of shRNA as a means to perturb specific redox couples may be misinterpreted if the targeted effects are not monitored in the context of potential global remodeling of the redox enzyme network. Results: Stable cell lines containing shRNA targets for glutaredoxin 1, thioredoxin … Show more

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